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Vol. 22, No. 1, 2006
Issue release date: June 2006
Dement Geriatr Cogn Disord 2006;22:60–66

The Effect of Apolipoprotein Polymorphism on Brain in Mild Cognitive Impairment: A Voxel-Based Morphometric Study

Pennanen C. · Testa C. · Boccardi M. · Laakso M.P. · Hallikainen M. · Helkala E.L. · Hänninen T. · Kivipelto M. · Könönen M. · Nissinen A. · Tervo S. · Vanhanen M. · Vanninen R. · Frisoni G.B. · Soininen H.
Departments of aNeurology and bClinical Radiology, Kuopio University Hospital, Departments of cNeuroscience and Neurology and dPublic Health, University of Kuopio, Kuopio, and eNational Institute of Public Health, Helsinki, Finland; fLaboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio – FBF, Brescia, gAssociazione Fatebenefratelli per la Ricerca, Rome, and hMachine Vision Laboratory, Department of Mathematics and Computer Science, University of Udine, Udine, Italy

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We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE ε4 (n = 15) and those who were ApoE ε4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the ε4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.

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