- Psoriatic arthritis
- Association study
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis (Ps). The precise etiology of PsA is unknown, but epidemiological studies supported the existence of a genetic component for the disease. Here we report an association study on a large PsA Italian cohort for DNA variants recently reported as associated alleles at PSORS2 (17q25) in Ps cohorts from the US. We focused on discovering a possible involvement of PSORS2 associated SNPs in pathogenesis of PsA. We selected two SNPs (rs7420, rs734232) within the proximal peak and two SNPs (rs869190 and rs1561946) within distal peak of PSORS2. Our results ruled out PSORS2 alleles as susceptibility factors in arthritis psoriatic patients of Italian origin and suggested that previous linkage signal reported for chromosome 17q25 should be independent on the presence of PsA.
Copyright © 2006 S. Karger AG, Basel
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Received: January 20, 2006
Accepted after revision: March 28, 2006
Published online: May 30, 2006
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 10
Human Heredity (International Journal of Human and Medical Genetics)
Vol. 61, No. 2, Year 2006 (Cover Date: June 2006)
Journal Editor: Devoto, M. (Philadelphia, Pa.)
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.com/HHE
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