Journal Mobile Options
Table of Contents
Vol. 213, No. 2, 2006
Issue release date: August 2006
Dermatology 2006;213:159–162

Acquired Melanocytic Naevus in Childhood Vulval Pemphigoid

Lebeau S. · Braun R.P. · Masouyé I. · Perrinaud A. · Harms M. · Borradori L.
Clinic of Dermatology, University Hospital, Geneva, Switzerland

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in


Background: Eruptive epidermolysis bullosa (EB) naevi comprise a subset of melanocytic naevi with atypical features that characteristically occur in areas of former blistering in patients suffering from hereditary EB. Observation: The case is reported of a girl who presented with pruritus, blistering and erosions of the vulval region. Clinical and immunopathological features were consistent with the diagnosis of childhood vulval pemphigoid. In the course of the disease, she developed an atypical melanocytic naevus on the left labium at a site of former blistering. Although its clinical and dermoscopic features resembled malignant melanoma, the lesion completely regressed clinically during the 24-month follow-up. Conclusion: This is the first report describing the development of a melanocytic naevus at sites of blistering in an auto-immune subepidermal blistering disease in childhood. Our observation extends the spectrum of disorders, in addition to the group of congenital EB, in which ‘eruptive’ atypical melanocytic naevi may occur. Knowledge of this complication is important for appropriate management and follow-up and to avoid radical surgery.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


  1. Laffitte E, Borradori L: Bullous pemphigoid and related disorders; in Hertl M (ed): Autoimmune Diseases of the Skin. Vienna, Springer, 2001, pp 63–83.
  2. Nemeth AJ, Klein AD, Gould EW, et al: Childhood bullous pemphigoid: clinical and immunologic features, treatment, and prognosis. Arch Dermatol 1991;127:378–386.
  3. Fisler RE, Saeb M, Liang MG, Howard RM, McKee PH: Childhood bullous pemphigoid: a clinicopathologic study and review of the literature. Am J Dermatopathol 2003;25:183–189.
  4. Farrell AM, Kirtschig G, Dalziel KL, et al: Childhood vulval pemphigoid: a clinical and immunopathological study of five patients. Br J Dermatol 1999;140:308–312.
  5. Saad RM, Domolge-Hultsch N, Yancey KB, Benson PM, James WD: Childhood localized vulvar pemphigoid is a true variant of bullous pemphigoid. Arch Dermatol 1992;128:807–810.
  6. Johr RH: Dermoscopy: alternative melanocytic algorithms – The ABCD rule of dermatoscopy, Menzies scoring method, and 7-point checklist. Clin Dermatol 2002;20:240–247.
  7. Hashimoto I, Schnyder UW, Anton-Lamprecht I: Epidermolysis bullosa hereditaria with junctional blistering in an adult. Dermatologica 1976;152:72–86.
  8. Bauer JW, Schaeppi H, Kaserer C, Hantich B, Hintner H: Large melanocytic nevi in hereditary epidermolysis bullosa. J Am Acad Dermatol 2001;44:577–584.
  9. Stavrianeas NG, Katoulis AC, Moussatou V, et al: Eruptive large melanocytic nevus in a patient with hereditary epidermolysis bullosa simplex. Dermatology 2003;207:402–404.
  10. Bichel J, Metze D, Bruckner-Tudermann L, Stauder S: Large melanocytic nevi in generalized atrophic benign epidermolysis bullosa (epidermolysis bullosa nevi). Hautarzt 2001;52:812–816.
  11. Hoss DM, McNutt NS, Carter DM, et al: Atypical melanocytic lesions in epidermolysis bullosa. J Cutan Pathol 1994;21:164–169.
  12. Christophoridis S, Budinger L, Borradori L, et al: IgG, IgA and IgE autoantibodies against the ectodomain of BP180 in patients with bullous and cicatricial pemphigoid and linear IgA bullous dermatosis. Br J Dermatol 2000;143:349–355.
  13. Virgili A, Zampino MR, Corazza M: Primary vulvar melanoma with satellite metastasis: dermoscopic findings. Dermatology 2004;208:145–148.
  14. Grubauer G, Hintner H, Klein G, Fritsch P: Acquired, surface giant nevus cell nevi in generalized, atrophic, benign epidermolysis bullosa. Hautarzt 1989;40:523–526.
  15. Soltani K, Pepper MC, Simjee S, Apatoff B: Large acquired nevocytic nevi induced by the Koebner phenomenon. J Cutan Pathol 1984;11:296–299.
  16. Lanschuetzer CM, Emberger M, Laimer M, Diem A, Bauer JW, Soyer HP, Hintner H: Epidermolysis bullosa naevi reveal a distinctive dermoscopic pattern. Br J Dermatol 2005;153:97–102.
  17. Kopf AW, Grupper C, Baer L, Mitchell JC: Eruptive nevocytic nevi after severe bullous disease. Arch Dermatol 1977;113:1080–1084.
  18. Goerz G, Tsambaos D: Eruptive nevocytic nevi after Lyell’s syndrome. Arch Dermatol 1978;114:1400–1401.
  19. Shoji T, Cockerell CJ, Koff AB, Bhawan J: Eruptive melanocytic nevi after Stevens-Johnson syndrome. J Am Acad Dermatol 1997;37:337–339.
  20. Fine JD, Eady RA, Bauer EA, Briggaman RA, Bruckner-Tuderman L, Christiano A, Heagerty A, Hintner H, Jonkman MF, McGrath J, McGuire J, Moshell A, Shimizu H, Tadini G, Uitto J: Revised classification system for inherited epidermolysis bullosa: report of the Second International Consensus Meeting on diagnosis and classification of epidermolysis bullosa. J Am Acad Dermatol 2000;42:1051–1066.
  21. Mattei S, Colombo MP, Melani C, et al: Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes. Int J Cancer 1994;56:853–857.
  22. Giomi B, Caproni M, Calzolari A, Bianchi B, Fabbri P: Th1, Th2 and Th3 cytokines in the pathogenesis of bullous pemphigoid. J Dermatol Sci 2002;30:116–128.
  23. Lanschuetzer CM, Emberger M, Hametner R, et al: Pathogenic mechanisms in epidermolysis bullosa naevi. Acta Derm Venereol 2003;83:332–337.

Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00