Journal Mobile Options
Table of Contents
Vol. 27, No. 1, 2006
Issue release date: July 2006
Neuroepidemiology 2006;27:28–32

Limited Impact of the Summer Heat Wave in France (2003) on Hospital Admissions and Relapses for Multiple Sclerosis

Tataru N. · Vidal C. · Decavel P. · Berger E. · Rumbach L.
aDepartment of Neurology and bCRCB2, Jean Minjoz University Hospital, Besançon, France

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in


Patients with multiple sclerosis (MS) often report worsening of symptoms with increased environmental temperature. The aim of this paper was to determine whether or not the heat wave of the summer of 2003 in France was responsible for an increase in hospital admissions and relapses in MS patients. MS patients who were hospitalized between January 1, 2000 and December 31, 2003 were identified, and we established which patients were suffering relapses. Hospitalization and relapse seasonality were examined and analyzed according to ambient temperature variations. We did not observe a greater number of hospital admissions and relapses during the summer of 2003 compared to the previous 3 years. Results showed that MS hospitalizations display a significant trough in the winter season, especially in December, but no significant peak season or month was observed. There was no statistically significant correlation between mean ambient temperature and the number of admissions and relapses. The adverse symptoms associated with high temperatures that are usually observed in MS patients may require rapid rises in ambient temperate or in internal body temperature.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


  1. Guthrie TC, Nelson DA: Influence of temperature changes on multiple sclerosis: critical review of mechanisms and research potential. J Neurol Sci 1995;129:1–8.
  2. Rasminsky M: The effects of temperature on conduction in demyelinated single nerve fibers. Arch Neurol 1973;28:287–292.
  3. Saul RF, Hayat G, Selhorst JB: Visual evoked potentials during hyperthermia. J Neuroophthalmol 1995;15:70–78.
  4. Buljevac D, Flach HZ, Hop WCJ, Hijdra D, Laman JD, Savelkoul HFJ, Van der Meché FGA, Van Doorn PA, Hintzen RQ: Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain 2002;125:952–960.
  5. Kohlmeier RE, DiMaio VJ, Kagan-Hallet K: Fatal hyperthermia in hot baths in individuals with multiple sclerosis. Am J Forensic Med Pathol 2000;21:201–203.
  6. Beenakker EAC, Oparina TI, Hartgring A, Teelken A, Arutjunyan AV, De Keyser J: Cooling garment treatment in MS: clinical improvement and decrease in leukocyte NO production. Neurology 2001;57:892–894.
  7. NASA/MS Cooling Study Group: A randomized controlled study of the acute and chronic effects of cooling therapy for MS. Neurology 2003;60:1955–1960.

    External Resources

  8. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS: Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121–127.
  9. Wonnacott TH, Wonnacott RJ: Introductory Statistics, ed 5. New York, Wiley, 1990, pp 550–555.
  10. Walter SD: Calendar effects in the analysis of seasonal data. Am J Epidemiol 1994;140:649–657.
  11. In VS, octobre 2003: Impact sanitaire de la vague de chaleur en France survenue en août 2003. Bilan et perspectives. Département des maladies chroniques et traumatismes – Département santé environnement.
  12. Ogawa G, Mochizuki H, Kanzaki M, Kaida K, Motoyoshi K, Kamakura K: Seasonal variation of multiple sclerosis exacerbations in Japan. Neurol Sci 2004;24:417–419.
  13. Sandyk R, Awerbuch GL: Multiple sclerosis: relationship between seasonal variations of relapse and age of onset. Int J Neurosci 1993;71:147–157.
  14. Auer DP, Schumann EM, Kumpfel T, Gossl C, Trenkwalder C: Seasonal fluctuations of gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol 2000;47:276–277.
  15. Rovaris M, Comi G, Sormani MP, Wolinsky JS, Ladkani D, Filippi M: Effects of seasons on magnetic resonance imaging-measured disease activity in patients with multiple sclerosis. Ann Neurol 2001;49:415–416.
  16. Dumas M, Jauberteau-Marchan MO: The protective role of Langerhans’ cells and sunlight in multiple sclerosis. Med Hypotheses 2000;55:517–520.
  17. Munger KL, Zhang SM, O’Reilly E, Hernan MA, Olek MJ, Willett WC, Ascherio AA: Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62:60–65.
  18. Van der Mei AF, Ponsonby AL, Dwyer T, Blizzard L, Simmons R, Taylmor BV, Butzkueven H, Kilpatrick T: Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. Br Med J 2003;327:316–321.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50