Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Facioscapulohumeral Muscular Dystrophy and Occurrence of Heart Arrhythmia

Trevisan C.P.a · Pastorello E.a · Armani M.a · Angelini C.a · Nante G.b · Tomelleri G.c · Tonin P.c · Mongini T.d · Palmucci L.d · Galluzzi G.e · Tupler R.G.f · Barchitta A.b
aDepartment of Neurosciences and bDepartment of Internal Medicine, University of Padua, Padua, cDepartment of Neurological Sciences and Vision, University of Verona, Verona, dDepartment of Neuroscience, University of Torino, Torino, eInstitute of Neurology, Catholic University, Policlinico Gemelli, Roma, and fLaboratory of Neurogenetics, University of Modena and Reggio Emilia, Modena, Italy Eur Neurol 2006;56:1–5 (DOI:10.1159/000094248)

Abstract

Background: Subjects with facioscapulohumeral muscular dystrophy (FSHD) do not generally suffer from significant cardiac symptoms. Although with heterogeneous results, studies reported to date indicate that heart alterations unrelated to cardiomyopathy are possible in FSHD. Patients and Methods: We describe the findings of a multicenter investigation aimed at detecting cardiac abnormalities in 83 FSHD patients, 44 males and 39 females with a mean age of 47 years. All patients underwent clinical heart examination, 12-lead electrocardiography and 24-hour Holter monitoring; echocardiography was also performed on most patients. Results: Among the 83 patients, 62 with no cardiovascular risk factors were identified. Ten of them manifested clinical or subclinical cardiac involvement: 5 reported symptoms represented mostly by frequent palpitations secondary to supraventricular arrhythmia and another 5 exhibited electrocardiographic signs of short runs of supraventricular paroxysmal tachycardia. In the absence of cardiovascular risk factors, we found symptoms or signs of heart involvement of mainly arrhythmic origin in 10 of our 83 FSHD patients (12%). Conclusions: Considering our data and those available in the literature as a whole, arrhythmic alterations seem to be detected more frequently than expected in FSHD patients.

 

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50