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Vol. 116, No. 3, 2006
Issue release date: October 2006
Section title: Original Paper
Acta Haematol 2006;116:181–185
(DOI:10.1159/000094678)

Immunoregulatory T Cells in the Peripheral Blood of Patients with Hodgkin’s Lymphoma

Baráth S. · Aleksza M. · Keresztes K. · Tóth J. · Sipka S. · Szegedi G. · Illés Á.
aThird Department of Internal Medicine, Institute of Internal Medicine, Medical and Health Science Center, University of Debrecen, bDepartment of Oncology, Medical and Health Science Center, University of Debrecen, and cResearch Group of Autoimmune Diseases, Hungarian Academy of Sciences, Debrecen, Hungary

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/11/2005
Accepted: 12/21/2005
Published online: 10/6/2006

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

We aimed at investigating the distribution of various types of immunoregulatory T cells in the peripheral blood of patients with Hodgkin’s lymphoma (HL) (n = 94) being in the state of long-lasting complete remission using flow cytometry. Healthy patients (n = 41) as ‘negative’ and patients in complete remission with breast cancer (n = 47) as ‘positive’ controls were investigated in the study. We found significant elevations in the number of CD4+CD25high naturally occurring regulatory T cells, CD4+/intracellular IL-10+ (Tr1) and CD8+/intracellular IL-10+ T cells in HL compared to the healthy controls. In carcinoma patients, however, the number of Tr1 and CD8+/IL-10+ T cells was higher than that in the other two groups. The increase in the number of CD4+CD25high T cells seems to be characteristic of HL compared to the two other types of regulatory T cells. This change exists for a long time and it seems to be a characteristic of HL and independent of the types of therapy and the duration of time since therapy.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/11/2005
Accepted: 12/21/2005
Published online: 10/6/2006

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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