Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Rethinking the Dementia Diagnoses in a Population-Based Study: What Is Alzheimer’s Disease and What Is Vascular Dementia?

A Study from the Kungsholmen Project Agüero-Torres H.a-c · Kivipelto M.a-c · von Strauss E.a-c
aAging Research Center (ARC), bDivision of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and cStockholm Gerontology Research Center, Stockholm, Sweden Dement Geriatr Cogn Disord 2006;22:244–249 (DOI:10.1159/000094973)

Abstract

Objective: To explore the hypothesis that older adults often are affected by more than one disease, making the differential diagnosis between Alzheimer’s disease (AD) and vascular dementia (VaD) difficult. Methods: Incident dementia cases (n = 308) from a population-based longitudinal study of people 75+ years were investigated. The DSM-III-R criteria were used for the clinical diagnosis of dementia. Data on vascular disorders (hypertension, cerebrovascular and ischemic heart diseases, heart failure, atrial fibrillation, diabetes) as well as type of onset/course of dementia were used retrospectively to reclassify dementias. Results: Only 47% of the AD cases were reclassified as pure AD without any vascular disorder. Among subjects with AD and with a vascular component, cerebrovascular disease was the most common (41%). Only 25% of VaD were reclassified as pure VaD. Further, 26% of the pure AD subjects developed a vascular disorder in the following 3 years. Conclusions: Both vascular and degenerative mechanisms may often contribute to the expression of dementia among the elderly. Most of the AD cases have vascular involvements, and pure dementia types in very old subjects constitute only a minority of dementia cases.

 

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50