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Table of Contents
Vol. 213, No. 3, 2006
Issue release date: October 2006
Dermatology 2006;213:228–233
(DOI:10.1159/000095041)

Antimicrobial Silk Clothing in the Treatment of Atopic Dermatitis Proves Comparable to Topical Corticosteroid Treatment

Senti G. · Steinmann L.S. · Fischer B. · Kurmann R. · Storni T. · Johansen P. · Schmid-Grendelmeier P. · Wüthrich B. · Kündig T.M.
Unit for Experimental Immunotherapy, Department of Dermatology, University of Zurich, Zurich, Switzerland

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Abstract

Background: Atopic dermatitis (AD) is aggravated by mechanical irritation and bacterial colonization. Objective: This study compared the efficacy of an antimicrobial silk fabric (DermaSilk®) with that of a topical corticosteroid in the treatment of AD. Methods: Fifteen children were enrolled and wore a dress, where the left side was made of DermaSilk and the right side was made of cotton. The right arm and leg were treated daily with the corticosteroid mometasone for 7 days. The treatment efficacy was measured with a modified EASI (Eczema Area and Severity Index) and with an assessment by the patients/parents and by a physician. All patients were evaluated at baseline, as well as 7 and 21 days after the initial examination. Results: All parameters showed that, irrespective of the treatment, there was a significant decrease of eczema after 7 days. No significant difference between DermaSilk-treated and corticosteroid-treated skin could be observed. Conclusion: DermaSilk showed potential to become an effective treatment of AD.



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