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Table of Contents
Vol. 66, No. 6, 2006
Issue release date: November 2006
Section title: Novel Insights from Clinical Practice
Horm Res 2006;66:268–272
(DOI:10.1159/000095545)

Hypercalcaemia in Relapsed Medulloblastoma 8 Years Post-Diagnosis; Evidence to Support PTHrP Production by Medulloblastoma Cells

Dharmaraj P. · Ball S. · Johnstone H. · Bailey S. · Clifford S.C. · Hale J. · Cheetham T.D.
Departments of aPaediatrics, bPaediatric Oncology, and cEndocrinology, Royal Victoria Infirmary, and dNorthern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 12/5/2005
Accepted: 5/15/2006
Published online: 11/30/2006

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: A 19-year-old male presented with symptomatic hypercalcaemia as the first manifestation of relapsed metastatic medulloblastoma. Management at the time of the initial presentation 8 years earlier was with surgical excision and craniospinal radiotherapy. His biochemistry at the time of relapse and studies of medulloblastoma cell lines provide an insight into the pathogenesis of his hypercalcaemia. Methods: Parathyroid hormone-related protein (PTHrP) was measured by immunoradiometric assay in blood, and in conditioned and control media from three medulloblastoma cell lines following 72 h growth. Results: The histology at initial presentation (11 years of age) and at the time of relapse (with bone marrow infiltration and widespread bony metastases) demonstrated medulloblastoma. Ionised calcium concentrations at relapse were 2.89 mmol/l and serum PTHrP levels were increased at the same time (2.7 pmol/l; normal range: 0.7–1.8 pmol/l). There was evidence of PTHrP production by one cell line (MHH-MED-8A) while results for both other lines tested were below the limit of detection. Conclusions: Relapse 8 years after diagnosis is unusual in medulloblastoma and for this relapse to manifest as hypercalcaemia is also very uncommon. Our investigations suggest that the clinical picture was a reflection of PTHrP production by medulloblastoma cells.


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 12/5/2005
Accepted: 5/15/2006
Published online: 11/30/2006

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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