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Table of Contents
Vol. 27, No. 3, 2006
Issue release date: October 2006
Neuroepidemiology 2006;27:143–153
(DOI:10.1159/000095761)

Chronic Psychological Distress and Risk of Alzheimer’s Disease in Old Age

Wilson R.S. · Arnold S.E. · Schneider J.A. · Kelly J.F. · Tang Y. · Bennett D.A.
aRush Alzheimer’s Disease Center, bRush Institute for Healthy Aging, and Departments of cNeurological Sciences, dBehavioral Sciences, and eInternal Medicine, Rush University Medical Center, Chicago, Ill., fCenter for Neurobiology and Behavior, and gDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pa., USA

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Abstract

Clinical and pathological data from the Rush Memory and Aging Project were used to test the hypothesis that distress proneness is associated with increased risk of Alzheimer’s disease (AD). More than 600 older persons without dementia completed a 6-item measure of neuroticism, a stable indicator of proneness to psychological distress. At annual intervals thereafter, they underwent uniform evaluations that included clinical classification of AD and administration of 18 cognitive tests. Those who died underwent brain autopsy from which composite measures of AD pathology were derived. During a mean of about 3 years of follow-up, 55 people were clinically diagnosed with AD. In analyses that controlled for age, sex, and education, persons with a high level of distress proneness (score = 24, 90th percentile) were 2.7 times more likely to develop AD than those not prone to distress (score = 6, 10th percentile). Adjustment for depressive symptomatology or frequency of cognitive, social, and physical activity did not substantially change this effect. Distress proneness was also associated with more rapid cognitive decline. Among 45 participants who died and underwent brain autopsy, distress proneness was unrelated to diverse measures of AD pathology and was inversely related to cognition after controlling for AD pathology. The results support the hypothesis that distress proneness is associated with increased risk of dementia and suggest that neurobiologic mechanisms other than AD pathology may underlie the association.



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References

  1. de Beurs E, Beekman ATF, Deeg DJH, van Dyck R, van Tiburg W: Predictors of change in anxiety symptoms of older persons: results from the Longitudinal Aging Study Amsterdam. Psychol Med 2000;30:515–527.
  2. Magnus K, Diener E, Fujita F, Pavot W: Extraversion and neuroticism as predictors of objective life events: a longitudinal analysis. J Pers Soc Psychol 1993;65:1046–1053.
  3. Ormel J, Wohlfarth T: How neuroticism, long-term difficulties, and life situation change influence psychological distress: a longitudinal model. J Pers Soc Psychol 1991;60:744–755.
  4. Costa PT, McCrae RR: Personality in adulthood: a six-year longitudinal study of self-reports and spouse ratings on the NEO personality inventory. J Pers Soc Psychol 1988;54:853–863.
  5. Hultsch D, Hertzog C, Small B, Dixon R: Use it or lose it: engaged lifestyle as a buffer of cognitive decline in aging? Psychol Aging 1999;14:245–263.
  6. Knutson B, Momenan JR, Rawlings RR, Fong GW, Hommer D: Negative associations of neuroticism with brain volume ratio in healthy humans. Biol Psychiatry 2001;50:685–690.
  7. McEwan B: Effects of adverse experiences for brain structure and function. Biol Psychiatry 2000;48:721–731.
  8. Saplosky RM, Romero LM, Munck AV: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000;21:55–89.
  9. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW: Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 1996;93:3908–3913.
  10. Hull AM: Neuroimaging findings in post-tramatic stress disorder. Br J Psychiatry 2002;81:102–110.
  11. Newcomer JW, Selke G, Melson AK, Hershey T, Craft S, Richards K, Alderson AL: Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Arch Gen Psychiatry 1999;56:527–533.
  12. Wilson RS, Evans DA, Bienias JL, Mendes de Leon CF, Schneider JA, Bennett DA: Proneness to psychological distress is associated with risk of Alzheimer’s disease. Neurology 2003;61:1479–1485.
  13. Wilson RS, Barnes LL, Bennett DA, Li Y, Bienias JL, Mendes de Leon CF, Evans DA: Proneness to psychological distress and risk of Alzheimer’s disease in a community population. Neurology 2005;64:380–382.
  14. Wilson RS, Bennett DA, Mendes de Leon CF, Bienias JL, Morris MC, Evans DA: Distress proneness and cognitive decline in a population of older persons. Psychoneuroendocrinology 2005;30:11–17.
  15. Arbuckle TY, Maag U, Pushkar D, Chaikelson JS: Individual differences in trajectory of intellectual development over 45 years of adulthood. Psychol Aging 1998;13:663–675.
  16. Jelicic M, Bosma H, Ponds RWHM, van Boxtel MPJ, Houx PJ, Jolles J: Neuroticism does not affect cognitive functioning in later life. Exp Aging Res 2003;29:73–78.
  17. Wetherell JL, Reynolds CA, Gatz M, Pedersen NL: Anxiety, cognitive performance and cognitive decline in normal aging. J Gerontol B Psychol Sci Soc Sci 2002;57:P246–P255.
  18. Strauss ME, Pasupathi M, Chatterjee A: Concordance between observers in descriptions of personality change in Alzheimer’s disease. Psychol Aging 1993;8:475–480.
  19. Breitner JCS, Costa PT: ‘At my wits’ end’: neuroticism and dementia. Neurology 2003;6:1468–1469.
  20. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon CF, Bienias JL, Wilson RS: The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 2005;25:163–175.
  21. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS/ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.
  22. Costa PT, McCrae RR: Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual. Odessa, Psychological Assessment Resources, 1992.
  23. Wilson RS, Bienias JL, Evans DA, Bennett DA: Religious Orders Study: overview and change in cognitive and motor speed. Aging Neuropsychol Cogn 2004;11:280–303.

    External Resources

  24. Morris J, Heyman A, Mohs R, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). 1. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 1989;39:1159–1165.
  25. Albert M, Smith L, Scherr P, Taylor J, Evans D, Funkenstein H: Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer’s disease. Int J Neurosci 1991;57:167–178.
  26. Wilson RS, Beckett LA, Barnes LL, Schneider JA, Bach J, Evans DA, Bennett DA: Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging 2002;17:179–193.
  27. Wechsler D: Wechsler Memory Scale – Revised Manual. San Antonio, Psychological Corporation, 1987.
  28. Kaplan EF, Goodglass H, Weintraub S: The Boston Naming Test. Philadelphia, Lea & Febiger, 1983.
  29. Nelson HE: National Adult Reading Test (NART): Test Manual. Windsor, NFER Nelson, 1982.
  30. Cooper JA, Sager HJ: Incidental and intentional recall in Parkinson’s disease: an account based on diminished attentional resources. J Clin Exp Neuropsychol 1993;15:713–731.
  31. Smith A: Symbol Digit Modalities Test Manual – Revised. Los Angeles, Western Psychological Services, 1982.
  32. Ekstrom RB, French JW, Harman HH, Kermen D: Manual for Kit of Factor-Referenced Cognitive Tests. Princeton, Educational Testing Service, 1976.
  33. Trenerry MR, Crosson B, DeBoe J, Leber WR: The Stroop Neuropsychological Screening Test. Odessa, Psychological Assessment Resources, 1989.
  34. Benton AL, Sivan AB, Hamsher K, Varney NR, Spreen O: Contributions to neuropsychologial assessment, ed 2. New York, Oxford University Press, 1994.
  35. Raven JC, Court JH. Raven J: Manual for Raven’s Progressive Matrices and Vocabulary: Standard Progressive Matrices. Oxford, Oxford Psychologists Press, 1992.
  36. Wilson RS, Barnes LL, Bennett DA: Assessment of lifetime participation in cognitively stimulating activities. J Clin Exp Neuropsychol 2003;25:634–642.
  37. Wilson RS, Barnes LL, Krueger KR, Hoganson G, Bienias JL, Bennett DA: Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc 2005;11:400–407.
  38. Wilson RS, Arnold SE, Tang Y, Bennett DA: Odor identification and decline in different cognitive domains in old age. Neuroepidemiology 2006;26:61–67.
  39. Kohout FJ, Berkman LF, Evans DE, Cornoni-Huntley J: Two shorter forms of the CES-D depression symptoms index. J Aging Health 1993;5:179–193.
  40. Radloff LS: The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385–401.

    External Resources

  41. Wilson RS, Krueger KR, Gu L, Bienias JL, Mendes de Leon CF, Evans DA: Neuroticism, extraversion, and mortality in a defined population of older persons. Psychosom Med 2005;67:839–840.
  42. Wilson RS, Mendes de Leon CF, Bennett DA, Evans DA: Depressive symptoms and cognitive decline in a community population of older persons. J Neurol Neurosurg Psychiatry 2004;75:126–129.
  43. Mendes de Leon CF, Glass TA, Berkman LF: Social engagement and disability in a community population of older adults: the New Haven EPESE. Am J Epidemiol 2003;157:633–642.
  44. McPhillips JB, Pellettera KM, Barrett-Conner E, Wingard DL, Criqui MH: Exercise patterns in a population of older adults. Am J Prev Med 1989;5:65–72.
  45. 1985 Health Interview Survey. Hyattsville, US Public Health Service, National Center for Health Statistics, 1985, Series 10, Publication No 160 PHHS (PHS) 86–1568.
  46. Wilson RS, Mendes de Leon CF, Barnes LL, Schneider JA, Bienias JL, Evans DA, Bennett DA: Participation in cognitively stimulating activities and risk of incident Alzheimer’s disease. JAMA 2002;287:742–748.
  47. Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS: The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol 2006;5:406–412.
  48. Mitchell TW, Nissanov J, Han LY, Mufson EJ, Schneider JA, Cochran EJ, Bennett DA, Lee VM, Trojanowski JQ, Arnold SE: Novel method to quantify neuropil threads in brains from elders with and without cognitive impairment. J Histochem Cytochem 2000;48:1627–1638.
  49. Cox DR: Regression models and life tables (with discussion). J R Stat Soc B 1972;74:187–220.
  50. Laird NM, Ware JH: Random-effects models for longitudinal data. Biometrics 1982;38:963–974.
  51. Wilson RS, Gilley DW, Bennett DA, Beckett LA, Evans DA: Person-specific paths of cognitive decline in Alzheimer’s disease and their relation to age. Psychol Aging 2000;15:18–28.
  52. SAS Institute Inc: SAS/STAT® User’s Guide, Version 8. Cary, SAS Institute, 2000.
  53. Droomers M, Schrijvers CT, van de Mheen H, Mackenbach J: Educational differences in leisure-time physical inactivity: a descriptive and explanatory study. Soc Sci Med 1998;47:1665–1676.
  54. Barnes LL, Mendes de Leon CF, Wilson RS, Bienias JL, Evans DA: Social resources and cognitive decline in a population of older African Americans and whites. Neurology 2004;63:2322–2326.
  55. Weuve J, Kang JH, Manson JE. Breteler MM, Ware JH, Grodstein F: Physical activity, including walking, and cognitive function in older women. JAMA 2004;292:1454–1461.
  56. Wilson RS, Li Y, Bienias JL, Bennett DA: Cognitive decline in old age: separating retest effects from the effects of growing older. Psychol Aging, in press.
  57. Magarinos AM, McEwan BS: Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: comparison of stressors. Neuroscience 1995;69:83–88.
  58. Magarinos AM, McEwan BS, Flugge G, Fuchs E: Chronic psychosocial stress causes apical dendrite atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 1996;16:3534–3540.
  59. Radley JJ, Sisti HM, Hao J, Rocher AB, McCall T, Hof PR, McEwan BS, Morrison JH: Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience 2004;125:1–6.
  60. Johren O, Flugge G, Fuchs E: Hippocampal glucocorticoid receptor expression in the tree shrew: regulation by psychosocial conflict. Cell Mol Neurobiol 1994;14:281–296.
  61. Herman JP, Adams D, Prewitt C: Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm. Neuroendocrinology 1995;61:180–190.
  62. Smith MA, Makino S, Kvetnansky R, Post RM: Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995;15:1768–1777.
  63. Rasmusson AM, Shi L, Duman R: Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology 2002;27:133–142.
  64. Webster MJ, Knable MB, O’Grady J, Orthman J, Weickert CS: Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol Psychiatry 2002;7:985–994.
  65. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN: Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in post-mortem brain of suicide subjects. Arch Gen Psychiatry 2003;60:804–815.
  66. Wood GE, Young LT, Reagan LP, Chen B, McEwan BS: Stress-induced structural remodeling in the hippocampus: prevention by lithium treatment. Proc Natl Acad Sci USA 2004;101:3973–3978.
  67. Shakesby AC, Anwyl R, Rowan MJ: Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents. J Neurosci 2002;22:3638–3644.


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