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Neuroepidemiology 2006;27:201–207

Reported Alcohol Consumption and Cognitive Decline: The Northern Manhattan Study

Wright C.B.a · Elkind M.S.V.a · Luo X.b · Paik M.C.b · Sacco R.L.a, c
aDivision of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons of Columbia University, and Departments of bBiostatistics and cEpidemiology, Mailman School of Public Health, Columbia University, New York, N.Y., USA
email Corresponding Author

 goto top of outline Key Words

  • Alcohol drinking
  • Cognition disorders
  • Apolipoprotein E4

 goto top of outline Abstract

Background: Moderate alcohol intake may slow cognitive decline, and both vascular and neurodegenerative mechanisms have been implicated. Methods: We examined reported alcohol intake and cognitive decline in a community-based cohort of Hispanic, black and white individuals (n = 1,428). The role of the apolipoprotein E ε4 (APOE4) allele as a modifier was also studied. Results and Conclusions: Reported drinking was as follows: 300 participants (21%) were ‘never’ drinkers, 622 (44%) ‘past’ drinkers, 145 (10%) reported taking less than 1 drink weekly, 330 (23%) 1 drink weekly up to 2 daily and 31 (2%) more than 2 drinks daily. A positive relationship was seen between reported alcohol intake and cognition. Drinking less than 1 drink a week (p = 0.09), between 1 drink weekly up to 2 drinks daily (p = 0.001) and more than 2 drinks daily (p = 0.003) were associated with less cognitive decline on the modified Telephone Interview for Cognitive Status compared to never drinkers. This dose-response relationship was not modified by the presence of an APOE4 allele in a subsample.

Copyright © 2006 S. Karger AG, Basel

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 goto top of outline Author Contacts

Clinton Wright, MD, MS
Division of Stroke and Critical Care
College of Physicians and Surgeons of Columbia University
NI-Room 640, 710 W 168th Street, New York, NY 10032 (USA)
Tel. +1 212 305 1710, Fax +1 212 305 1658, E-Mail

 goto top of outline Article Information

Published online: October 16, 2006
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 2, Number of References : 41

 goto top of outline Publication Details


Vol. 27, No. 4, Year 2006 (Cover Date: December 2006)

Journal Editor: Román, G.C. (San Antonio, Tex.)
ISSN: 0251–5350 (print), 1423–0208 (Online)

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