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It is widely accepted that energy intake restriction without essential nutrient deficiency
delays the onset of aging and extends life span. The mechanism underlying this phenomenon
is still unknown though a number of different, nonmutually exclusive explanations have been
proposed. In each of these, different facets of physiology play the more significant role in the
mechanism of aging retardation. Some examples include the altered lipid composition
model, the immune response model and models describing changes in endocrine function. In
this paper we propose the hypothesis that metabolic reprogramming is the key event in the
mechanism of dietary restriction, and the physiological effects at the cellular, tissue and
organismal level may be understood in terms of this initial event.
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