Background/Aims: To compare the prevalence and characteristics of depression in vascular dementia (VaD) and Alzheimer’s disease (AD) after adjusting for dementia severity and gender. Methods: One hundred and eight pairs of VaD and AD patients matched for dementia severity and gender were assessed. Results: Major depressive disorder (MDD) was more prevalent in the VaD group than in the AD group (20.4% in VaD, 10.2% in AD, p = 0.04, Cochran-Mantel-Haenszel, CMH, test) regardless of the dementia severity and gender. The odds ratio for developing MDD in the VaD group versus the AD group was estimated to be 2.20 (95% confidence interval = 1.02–4.74). Neurovegetative symptoms such as ‘felt tired and weak all the time’ (30.6% in VaD, 13.9% in AD, p = 0.003, CMH test) and ‘changed weight without trying’ (16.7% in VaD, 6.5% in AD, p = 0.02, CMH test) were more prevalent in the VaD group than in the AD group. Conclusion: Depression in VaD was quantitatively and qualitatively different from that in AD regardless of the severity of dementia and gender; depression was more prevalent, severer and more retarded and vegetative in VaD than in AD.
© 2007 S. Karger AG, Basel
- Major depressive disorder
- Minor depressive disorder
- Vascular dementia
- Alzheimer’s disease
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Ki Woong Kim, MD, PhD
Department of Neuropsychiatry, Seoul National University College of Medicine and
Seoul National University Bundang Hospital
300 Gumidong, Bundanggu, Seongnamsi, Gyeonggido 463-707 (Korea)
Tel. +82 31 787 7432, Fax +82 31 787 4058, E-Mail email@example.com
Accepted: September 20, 2006
Published online: November 15, 2006
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 48
Dementia and Geriatric Cognitive Disorders
Vol. 23, No. 2, Year 2007 (Cover Date: January 2007)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/DEM
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