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Vol. 84, No. 4, 2006
Issue release date: February 2007
Section title: Neurosteroids and Neuroprotection
Neuroendocrinology 2006;84:275–279
(DOI:10.1159/000097485)

Cross-Talk between IGF-I and Estradiol in the Brain: Focus on Neuroprotection

Garcia-Segura L.M. · Sanz A. · Mendez P.
aInstituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; bDépartement des Neurosciences Fondamentales, Centre Médical Universitaire, Geneva, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Neurosteroids and Neuroprotection

Published online: 3/5/2007

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

The actions of estradiol in the brain involve the interaction with growth factors, such as insulin-like growth factor-I (IGF-I). Many cells in the brain coexpress receptors for estradiol (ERs) and IGF-I (IGF-IR) and both factors interact to regulate neural function. Several studies have shown that there is an interaction of IGF-IR and ERs in neuroprotection. Neuroprotective effects of estradiol are blocked by the inhibition of IGF-IR signaling, while the neuroprotective effects of IGF-I are blocked by the inhibition of ER signaling. These findings suggest that the neuroprotective actions of estradiol and IGF-I after brain injury depend on the coactivation of both ERs and IGF-IR in neural cells. The relationship of ERα with IGF-IR through the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3β (PI3K/Akt/GSK3) signaling pathway may represent the point of convergence used by estradiol and IGF-I to cooperatively promote neuroprotection. Administration of estradiol to ovariectomized rats results in the association of ERα with IGF-IR and with components of the PI3K/Akt/GSK3 signaling pathway and in the regulation of the activity of Akt and GSK3 in the brain. Conversely, IGF-I regulates ERα transcriptional activity in neuroblastoma cells and the PI3K/Akt/GSK3 signaling pathway is involved in this effect.


Article / Publication Details

First-Page Preview
Abstract of Neurosteroids and Neuroprotection

Published online: 3/5/2007

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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