Journal Mobile Options
Table of Contents
Vol. 67, Suppl. 1, 2007
Issue release date: February 2007

Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function

van Cauter E. · Holmbäck U. · Knutson K. · Leproult R. · Miller A. · Nedeltcheva A. · Pannain S. · Penev P. · Tasali E. · Spiegel K.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Background: Sleep exerts important modulatory effects on neuroendocrine function and glucose regulation. During the past few decades, sleep curtailment has become a very common behavior in industrialized countries. This trend toward shorter sleep times has occurred over the same time period as the dramatic increases in the prevalence of obesity and diabetes. Aims: This article will review rapidly accumulating laboratory and epidemiologic evidence indicating that chronic partial sleep loss could play a role in the current epidemics of obesity and diabetes. Conclusions: Laboratory studies in healthy young volunteers have shown that experimental sleep restriction is associated with a dysregulation of the neuroendocrine control of appetite consistent with increased hunger and with alterations in parameters of glucose tolerance suggestive of an increased risk of diabetes. Epidemiologic findings in both children and adults are consistent with the laboratory data.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Van Cauter E, Plat L, Copinschi G: Interrelations between sleep and the somatotropic axis. Sleep 1998;21:553–566.
  2. Kripke D, Simons R, Garfinkel L, Hammond E: Short and long sleep and sleeping pills. Is increased mortality associated? Arch Gen Psychiatry 1979;36:103–116.
  3. Gallup Organization: Sleep in America. Princeton, NJ: Gallup Organization, 1995.
  4. National Center for Health Statistics: QuickStats: percentage of adults who reported an average of ≤6 h of sleep per 24-hour period, by sex and age group ± United States, 1985 and 2004. MMWR. Morbidity and Mortality Weekly Report 2005.
  5. Ancoli-Israel S: Sleep problems in older adults: putting myths to bed. Geriatrics 1997;52:20–30.
  6. Buysse DJ, Hubbard R, Ombao H, Houck P, Monk TH: Sleep-dependent and circadian influences on normal nocturnal sleep. Sleep 2001;24:A1.
  7. Buysse DJ, Monk TH, Carrier J, Rose L, Begley A, Ombao H: Sleep ability and sleep need in aging: insights from a 90-minute day study. Sleep 2001;24:A2–A3.
  8. Wehr T, Moul D, Barbato G, Giesen H, Seidel J, Barker C, Bender C: Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol 1993;265:R846–R857.
  9. Andersen C, Maislin G, Van Dongen H, Rogers N, Powell J, Carlin M, Mullington J, Dinges D: Effect of chronically reduced nocturnal sleep, with and without daytime naps, on neurobehavioral performance. Sleep 2000;Abstract Supplement 2:A74–A75.
  10. Wright K Jr, Hughes R, Hull J, Czeisler C: Cumulative neurobehavioral performance deficits on a 24-hour day with 8-hour of scheduled sleep. Sleep 2000;23:A21.
  11. Carskadon MA, Acebo C: Regulation of sleepiness in adolescents: update, insights, and speculation. Sleep 2002;25:606–614.
  12. Spiegel K, Leproult R, Van Cauter E: Impact of sleep debt on metabolic and endocrine function. Lancet 1999;354:1435–1439.
  13. Spiegel K, Leproult R, L’Hermite-Baleriaux M, Copinschi G, Penev P, Van Cauter E: Leptin levels are dependent on sleep duration: relationships with sympatho-vagal balance, carbohydrate regulation, cortisol and TSH. J Clin Endocrinol Metab 2004;89:5762–5771.
  14. Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E: Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol 2005;99:2008–2019.
  15. Bergman RN, Ader M, Huecking K, Van Citters G: Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 2002;51(suppl 1):S212–S220.
  16. Xiang AH, Peters RK, Kjos SL, Marroquin A, Goico J, Ochoa C, Kawakubo M, Buchanan TA: Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes. Diabetes 2006;55:517–522.
  17. Spiegel K, Tasali E, Penev P, Van Cauter E: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels and increased hunger and appetite. Ann Intern Med 2004;141:846–850.
  18. van der Lely AJ, Tschop M, Heiman M, Ghigo E: Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004;25:426–457.
  19. Taheri S, Lin L, Austin D, Young T, Mignot E: Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 2004;1:e62.
  20. Vioque J, Torres A, Quiles J: Time spent watching television, sleep duration and obesity in adults living in Valencia, Spain. Int J Obes Relat Metab Disord 2000;24:1683–1688.
  21. Shigeta H, Shigeta M, Nakazawa A, Nakamura N, Yoshikawa T: Lifestyle, obesity, and insulin resistance. Diabetes Care 2001;24:608.
  22. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR: Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 2002;59:131–136.
  23. Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB: A prospective study of sleep duration and mortality risk in women. Sleep 2004;27:440–444.
  24. Cournot M, Ruidavets JB, Marquie JC, Esquirol Y, Baracat B, Ferrieres J: Environmental factors associated with body mass index in a population of Southern France. Eur J Cardiovasc Prev Rehabil 2004;11:291–297.
  25. Vorona R, Winn M, Babineau T, Eng B, Feldman H, Ware J: Overweight and obese patients in a primary care population report less sleep than patients with a normal body mass index. Arch Intern Med 2005;165:25–30.
  26. Singh M, Drake CL, Roehrs T, Hudgel DW, Roth T: The association between obesity and short sleep duration: a population-based study. J Clin Sleep Med 2005;1:357–363.
  27. Gangwisch JE, Malaspina D, Boden-Albala B, Heymsfield SB: Inadequate sleep as a risk factor for obesity: analyses of the NHANES I. Sleep 2005;28:1289–1296.
  28. Hasler G, Buysse D, Klaghofer R, Gamma A, Ajdacic V, Eich D, Rössler W, Angst J: The association between short sleep duration and obesity in young adults: a 13-year prospective study. Sleep 2004;27:661–666.
  29. Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, Patel S, Hu FB: A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 2003;26:380–384.
  30. Mallon L, Broman JE, Hetta J: High incidence of diabetes in men with sleep complaints or short sleep duration: a 12-year follow-up study of a middle-aged population. Diabetes Care 2005;28:2762–2767.
  31. Bjorkelund C, Bondyr-Carlsson D, Lapidus L, Lissner L, Mansson J, Skoog I, Bengtsson C: Sleep disturbances in midlife unrelated to 32-year diabetes incidence: the prospective population study of women in Gothenburg. Diabetes Care 2005;28:2739–2744.
  32. Yaggi HK, Araujo AB, McKinlay JB: Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care 2006;29:657–661.
  33. Locard E, Mamelle N, Billette A, Miginiac M, Munoz F, Rey S: Risk factors of obesity in a five year old population. Parental versus environmental factors. Int J Obes Relat Metab Disord 1992;16:721–729.
  34. Gupta NK, Mueller WH, Chan W, Meininger JC: Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol 2002;14:762–768.
  35. von Kries R, Toschke AM, Wurmser H, Sauerwald T, Koletzko B: Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep – a cross-sectional study. Int J Obes Relat Metab Disord 2002;26:710–716.
  36. Sekine M, Yamagami T, Hamanishi S, Handa K, Saito T, Nanri S, Kawaminami K, Tokui N, Yoshida K, Kagamimori S: Parental obesity, lifestyle factors and obesity in preschool children: results of the Toyama Birth Cohort Study. J Epidemiol 2002;12:33–39.

    External Resources

  37. Agras WS, Hammer LD, McNicholas F, Kraemer HC: Risk factors for childhood overweight: a prospective study from birth to 9.5 years. J Pediatr 2004;145:20–25.
  38. Reilly J, Armstrong J, Dorosty A, Emmett P, Ness A, Rogers I, Steer C, Sherriff A: Early life risk factors for obesity in childhood: cohort study. BMJ 2005;doi:10.1136/bmj.38470. 670903.E0.
  39. Chaput JP, Brunet M, Tremblay A: Relationship between short sleeping hours and childhood overweight/obesity: results from the ‘Quebec en Forme’ Project. Int J Obes (Lond) 2006;30(7):1080–1085. Epub 2006 Mar 14.

    External Resources

  40. Knutson KL: Sex differences in the association between sleep and body mass index in adolescents. J Pediatr 2005;147:830–834.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50