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Expansion Cranioplasty with Jackscrew Distracters for Craniosynostosis and Intracranial Hypertension in Transplanted Osteopetrosis

Dowlati D.a · Winston K.R.a · Ketch L.L.a · Quinones R.b · Giller R.b · Frattini A.c · van Hove J.b
Departments of aNeurosurgery and bPediatrics, The University of Colorado Health Sciences Center and The Children’s Hospital, Denver, Colo., USA; cDepartment of Human Genome, Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy Pediatr Neurosurg 2007;43:102–106 (DOI:10.1159/000098381)


Background: An 11-month-old boy with autosomal recessive infantile osteopetrosis presented, 7 months after bone marrow transplantation, with normal ventricular size and life-threatening intracranial hypertension due to pansynostosis. Methods: The cranial vault was expanded by using jackscrew distracters to upwardly advance the upper part of the calvarium. Results: The procedure achieved a 15-mm upward expansion of the cranial vault over a 15-day period, and the volume of the cranial vault was increased by 139 ml. All clinical manifestations of intracranial hypertension resolved. Conclusion: Cranial vault expansion with jackscrew distracters was successful in relieving intracranial hypertension in an infant with pancraniosynostosis complicating bone marrow transplanted malignant infantile osteopetrosis.


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