- PDZ domain
- BAR domain
- Protein trafficking
- AMPA receptor
- Long-term potentiation
- Long-term depression
- Synaptic plasticity
- Lipid binding
PICK1 is a peripheral membrane protein conserved from Caenorhabditis elegans to the human. It is expressed in many tissues with high levels in brain and testis. Inside cells, PICK1 is localized at the perinuclear region as well as specialized structures such as synapses of neurons. PICK1 contains a PDZ domain and a BAR domain. The PDZ domain of PICK1 binds to a large number of membrane proteins, especially proteins with C-terminal type II PDZ-binding motifs. The BAR domain of PICK1 binds to lipid molecules, mainly phosphoinositides. While the PDZ domain and the linker region of PICK1 enhance BAR domain’s lipid binding, the C-terminal region of PICK1 inhibits its lipid binding. PICK1 regulates the subcellular localization and surface expression of its PDZ-binding partners. Lipid binding of PICK1’s BAR domain is important for this regulation. With its PDZ domain interacting with membrane proteins and its BAR domain binding to lipids, the unique structure of PICK1 enables it to couple membrane proteins to protein-trafficking machinery.
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Dr. Jun Xia
Department of Biochemistry
The Hong Kong University of Science and Technology
Kowloon, Hong Kong, SAR (China)
Tel. +852 2358 7274, Fax +852 2358 1552, E-Mail email@example.com
Received: September 2, 2006
Accepted after revision: October 11, 2006
Published online: January 11, 2007
Number of Print Pages : 12
Number of Figures : 4, Number of Tables : 1, Number of References : 73
Vol. 15, No. 4, Year 2006/2007 (Cover Date: June 2007)
Journal Editor: Ip, N.Y. (Hong Kong)
ISSN: 1424–862X (print), 1424–8638 (Online)
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