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Vol. 64, No. 2, 2007
Issue release date: August 2007
Gynecol Obstet Invest 2007;64:65–68

Midtrimester Amniotic Fluid Leptin and Insulin Levels and Subsequent Gestational Diabetes

D’Anna R. · Baviera G. · Cannata M.L. · De Vivo A. · Di Benedetto A. · Corrado F.
Departments of aObstetrics and Gynecology and bInternal Medicine, University of Messina, Messina, Italy

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Aims: To evaluate midtrimester amniotic fluid leptin levels in pregnancies subsequently complicated by gestational diabetes. Methods: We studied 32 pregnant women with gestational diabetes and a control group of 43 normal pregnancies with an adequate gestational age fetus. All underwent a midtrimester amniocentesis: leptin and insulin were measured in the amniotic fluid. Data were compared with the Mann-Whitney U-test. Results: Median leptin concentrations in the amniotic fluid of the gestational diabetes mellitus patients were significantly higher than in the control group (15.1 vs. 7.9 ng/ml) (p = 0.001); amniotic insulin concentrations were also higher in the gestational diabetes mellitus than in the control group (0.67 vs. 0.38 µU/ml) (p = 0.02). Furthermore, amniotic fluid leptin levels were directly correlated with amniotic insulin concentrations; instead, there was no correlation with maternal BMI and birth weight. Conclusion: Our data suggest that in pregnancies subsequently complicated by gestational diabetes, amniotic fluid leptin and insulin levels are higher in the early fetal period.

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