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Vol. 23, No. 4, 2007
Issue release date: March 2007
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;23:215–218
(DOI:10.1159/000099471)

Interaction between Poly(ADP-Ribose) Polymerase 1 and Interleukin 1A Genes Is Associated with Alzheimer’s Disease Risk

Infante J. · Llorca J. · Mateo I. · Rodríguez-Rodríguez E. · Sánchez-Quintana C. · Sánchez-Juan P. · Fernández-Viadero C. · Peña N. · Berciano J. · Combarros O.
aNeurology Service, Marqués de Valdecilla University Hospital, University of Cantabria, bDivision of Preventive Medicine, University of Cantabria School of Medicine, and cRTE Santander, Consejería de Sanidad, Santander, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 9/1/2006
Accepted: 10/25/2006
Published online: 2/9/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Excessive release of proinflammatory cytokines by activated microglia surrounding senile plaques might contribute to the neurodegeneration associated with Alzheimer’s disease (AD). Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes, like interleukin 1 (IL-1). As PARP-1 overactivity has been shown in the AD brain, we tested the hypothesis that the PARP-1 –410 and –1672 polymorphisms would predispose people to AD due to overexpression of the PARP-1 gene, independently or in concert with the proinflammatory IL-1A –889 polymorphism. So, we performed a case-control study in 263 Spanish AD patients and 293 healthy controls. PARP-1 –410 and PARP-1 –1672 haplotypes were associated with an increased risk for AD (global haplotype association p value = 0.019), and, in addition, PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A –889 allele 2.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 9/1/2006
Accepted: 10/25/2006
Published online: 2/9/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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    External Resources

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