Journal Mobile Options
Table of Contents
Vol. 214, No. 3, 2007
Issue release date: March 2007
Section title: Clinical and Laboratory Investigations
Dermatology 2007;214:227–230
(DOI:10.1159/000099587)

Congenital Melanocytic Nevus: An Epidemiologic Study in Italy

Ingordo V. · Gentile C. · Iannazzone S.S. · Cusano F. · Naldi L.
aDepartment of Dermatology, Italian Navy Main Hospital ‘G. Venticinque’, and bDraft’s Council Medical Unit, Italian Navy, Taranto, cDepartment of Dermatology, ‘G. Rummo’ Hospital, Benevento, and dCoordinating Center, Italian Group for Epidemiological Research in Dermatology (GISED), Department of Dermatology, Ospedali Riuniti, Bergamo, Italy

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 33.00
Account: USD 23.00

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 8/9/2006
Accepted: 9/14/2006
Published online: 3/23/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: The prevalence of congenital melanocytic nevi (CMN) among newborns ranges between 0.2 and 6% in the worldwide literature. In the only available study from Italy the rate was 1% at birth and 1.4% at 2 years of age. Some surveys performed among samples of children and adolescents in other countries showed a prevalence which ranged from 1.4 to 4.4%. Additional data on the frequency in adults are not available. Objective: The aim of this study was to estimate the prevalence of CMN in a large sample of a young male Italian population, which is deemed to be representative of the general population of the same age and sex. Methods: The potential conscripts resident in the coastal regions of southern Italy, enlisted for the compulsory service in the Italian Navy, were called at the age of 18 to the Draft’s Council Medical Unit of the Italian Navy in Taranto to evaluate their psychophysical fitness to recruitment. All the subjects examined from September 2002 to March 2004 showing skin lesions evocative of CMN were referred by general practitioners of the Draft’s Council Medical Unit to the Department of Dermatology of the Italian Navy Hospital for confirming the diagnosis, which was based on the clinical features and the personal history. The confirmed cases were recorded in a predefined patient card, containing the main anamnestic and clinical data. Since the screening of small CMN in such a large sample of subjects was believed to be difficult, only CMN with a diameter ≧1.5 cm were recorded. Results: In 23,354 examined persons 157 CMN were diagnosed, with a prevalence of 0.67% (Bayesian 95% confidence interval 0.57–0.79); 126 (80.3%) CMN were medium-sized (≧1.5 and ≤19.9 cm in diameter), and 31 (19.7%) were large (≧20 cm in diameter). Three CMN (1.9%) were located on the face, 23 (14.6%) on the chest, 24 (15.2%) on the abdomen, 36 (22.9%) on the back, 48 (30.5%) on the lumbar area, 15 (9.5%) on the upper limb, 19 (12.1%) on the lower limb and 15 (9.5%) on the shoulder. No CMN was located on the head. In 19 cases (12.1%) ≧2 adjacent anatomical sites (shoulder/chest, shoulder/arm, etc.) were involved. In 73 moles (46.4%) terminal hairs were present. Eight CMN (5.1%) showed a zosteriform (i.e. segmental) feature. None of the examined subjects reported a personal history of malignant melanoma (MM), and no person with a history of MM was observed among all the enlisted men referred to the Department of Dermatology during the time of the study. Conclusion: The prevalence of CMN in the Italian young male general population is roughly in agreement with the rates detected in general populations from other European studies. The observations of this study also suggest that the risk of appearance of MM, at least in childhood and adolescence, is limited for medium-sized CMN.


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 8/9/2006
Accepted: 9/14/2006
Published online: 3/23/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Rhodes AR, Albert LS, Weinstock MA: Congenital nevomelanocytic nevi: proportionate area expansion during infancy and early childhood. J Am Acad Dermatol 1996;34:51–62.
  2. Kopf AW, Bart RS, Hennessey P: Congenital nevi and malignant melanomas. J Am Acad Dermatol 1979;1:123–130.
  3. DeDavid M, Orlow SJ, Provost N, Marghoob AA, Rao BK, Wasti Q, Huang CL, Kopf AW, Bart RS: Neurocutaneous melanosis: clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis. J Am Acad Dermatol 1996;35:529–538.
  4. Ingordo V, Gentile C, Iannazzone SS, Cusano F, Naldi L: The ‘EpiEnlist’ project: a dermo-epidemiologic study on a representative sample of young Italian males: prevalence of selected pigmentary lesions. Submitted.
  5. Seidenari S, Martella G, Pellacani G: Polarized light-surface microscopy for description and classification of small and medium-sized congenital melanocytic naevi. Acta Derm Venereol 2003;83:1–6.
  6. Walton RG, Jacobs AH, Cox AJ: Pigmented lesions in newborn infants. Br J Dermatol 1976;95:389–396.
  7. Alper J, Holmes LB: The incidence and significance of birthmarks in a cohort of 4641 newborns. Pediatr Dermatol 1983;1:58–78.
  8. Osburn K, Schosser RH, Everett MA: Congenital pigmented and vascular lesions in newborn infants. J Am Acad Dermatol 1987;16:788–792.
  9. Castilla EE, da Graca Dutra MG, Orioli-Parreiras IM: Epidemiology of congenital pigmented naevi. 1. Incidence rates and relative frequencies. Br J Dermatol 1981;104:307–314.
  10. Karvonen SL, Vaajalahti P, Marenk M, Janas M, Kuokkanen K: Birthmarks in 4346 Finnish newborns. Acta Derm Venereol (Stockh) 1992;72:55–57.
  11. Plantin P, Delaire P, Gavanou J, Boog G, Guillet G: Benign cutaneous lesions observed within the 1st 48 hours of life in 874 infants born at a maternity ward of a university hospital: apropos of 148 cases. Ann Dermatol Venereol 1990;117:181–184.
  12. Kroon S, Clemmensen OJ, Hastrup N: Incidence of congenital melanocytic nevi in newborn babies in Denmark. J Am Acad Dermatol 1987;16:788–792.
  13. Lorenz S, Maier C, Segerer H, Landthaler M, Hohenleutner U: Skin changes in newborn infants in the first 5 days of life. Hautarzt 2000;51:396–400.
  14. Berg P, Lindelof B: Congenital melanocytic naevi and cutaneous melanoma. Melanoma Res 2003;13:441–445.
  15. Goss BD, Forman D, Ansell PE, Bennett V, Swerdlow AJ, Burge S, Ryan TJ: The prevalence and characteristics of congenital pigmented lesions in newborn babies in Oxford. Paediatr Perinat Epidemiol 1990;4:448–457.
  16. Zina G, Bundino S, Ubertalli S, Garinelli R: Studio clinico-evolutivo dei nevi congeniti su di un campione di 3073 neonati. G Ital Dermatol Venereol 1985;120:5–15.
  17. Valiukeviciene S, Miseviciene I, Gollnick H: The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania. Arch Dermatol 2005;141:579–586.
  18. Synnerstad I, Nilsson L, Fredrikson M, Rosdahl I: Frequency and distribution pattern of melanocytic naevi in Swedish 8–9-year-old children. Acta Derm Venereol 2004;84:271–276.
  19. McLean DI, Gallagher RP: ‘Sunburn’ freckles, café-au-lait macules, and other pigmented lesions of schoolchildren: the Vancouver Mole Study. J Am Acad Dermatol 1995;32:565–570.
  20. Garcia Moran JI, Jarabo Garcia MT: Congenital melanocytic nevi: a study of 23 cases in a health center. An Esp Pediatr 1996;44:545–547.
  21. Tannous ZS, Mihm MC Jr, Sober AJ, Duncan LM: Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management. J Am Acad Dermatol 2005;52:197–203.
  22. Soyer HP, Braun RP, Argenziano G: Dermoscopy coming of age. Dermatology 2006;212:266–267.

    External Resources

  23. Seidenari S, Pellacani G, Martella A, Giusti F, Argenziano G, Buccini P, Carli P, Catricalà C, De Giorgi V, Ferrari A, Ingordo V, Manganoni AM, Peris K, Piccolo D, Pizzichetta MG: Instrument-, age-, and site-dependent variations of dermoscopic patterns of congenital melanocytic nevi: a multicenter study. Br J Dermatol 2006;155:56–61.
  24. Ingordo V, Iannazzone SS, Cusano F, Naldi L: Dermoscopic features of congenital melanocytic nevus and Becker nevus in an adult male population: an analysis with a 10-fold magnification. Dermatology 2006;212:354–360.
  25. Rhodes AR, Wood WC, Sober AJ, Mihm MC Jr: Nonepidermal origin of malignant melanoma associated with giant congenital nevocellular nevus. Plast Reconstr Surg 1981;67:782–790.
  26. Quaba AA, Wallace AF: The incidence of malignant melanoma (0 to 15 years of age) arising in ‘large’ congenital nevocellular nevi. Plast Reconstr Surg 1986;78:174–181.
  27. Marghoob AA, Schoenbach SP, Kopf AW, Orlow SJ, Nossa R, Bart RS: Large congenital melanocytic nevi and the risk for the development of malignant melanoma: a prospective study. Arch Dermatol 1996;132:170–175.
  28. DeDavid M, Orlow SJ, Provost N, Marghoob AA, Rao BK, Huang CL, Wasti Q, Kopf AW, Bart RS: A study of large congenital melanocytic nevi and associated malignant melanomas: review of cases in the New York University Registry and the world literature. J Am Acad Dermatol 1997;36:409–416.
  29. Swerdlow AJ, English JSC, Qiao Z: The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol 1995;32:595–599.
  30. Bittencourt FV, Marghoob AA, Kopf AW, Koenig KL, Bart RS: Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis. Pediatrics 2000;106:736–741.
  31. Gari LM, Rivers JK, Kopf AW: Melanomas arising in large congenital nevocytic nevi: a prospective study. Pediatr Dermatol 1988;5:151–158.
  32. Egan CL, Oliveria SA, Elenitsas R, Hanson J, Halpern AC: Cutaneous melanoma risk and phenotypic changes in large congenital nevi: a follow-up study of 46 patients. J Am Acad Dermatol 1998;39:923–932.
  33. Bett BJ: Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons. J Am Acad Dermatol 2005;52:793–797.
  34. Ruiz-Maldonado R, Tamayo L, Laterza AM, Duran C: Giant pigmented nevi: clinical, histopathologic, and therapeutic considerations. J Pediatr 1992;120:906–911.
  35. Lorentzen M, Pers M, Bretteville-Jensen G: The incidence of malignant transformation in giant pigmented nevi. Scand J Plast Reconstr Surg 1977;11:163–167.
  36. Hale EK, Stein J, Ben-Porat L, Panageas KS, Eichenbaum MS, Marghoob AA, Osman I, Kopf AW, Polsky D: Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi – results from the NYU-LCMN registry. Br J Dermatol 2005;152:512–517.
  37. Rhodes AR, Sober AJ, Day CL, Melski JW, Harrist TJ, Mihm MC Jr, Fitzpatrick TB: The malignant potential of small congenital nevocellular naevi: an estimate of association based on a histologic study of 234 primary cutaneous melanomas. J Am Acad Dermatol 1982;6:230–241.
  38. Rhodes AR, Melski JW: Small congenital nevocellular nevi and the risk of cutaneous melanoma. J Pediatr 1982;100:219–224.
  39. Kaddu S, Smolle J, Zenahlik P, Hofmann-Wellenhof R, Kerl H: Melanoma with benign melanocytic naevus components: reappraisal of clinicopathological features and prognosis. Melanoma Res 2002;12:271–278.
  40. Illig L, Weidner F, Hundeiker M, Gartmann H, Biess B, Leyh F, Paul E: Congenital nevi less than or equal to 10 cm as precursors to melanoma. 52 cases, a review, and a new conception. Arch Dermatol 1985;121:1274–1281.
  41. Sahin S, Levin L, Kopf AW, Rao BK, Triola M, Koenig K, Huang C, Bart R: Risk of melanoma in medium-sized congenital melanocytic nevi: a follow-up study. J Am Acad Dermatol 1998;39:428–433.
  42. Makkar HS, Frieden IJ: Congenital melanocytic nevi: an update for the paediatrician. Curr Opin Pediatr 2002;14:397–403.