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Vol. 214, No. 3, 2007
Issue release date: March 2007
Dermatology 2007;214:268–271

Multicentric Reticulohistiocytosis-Mimicking Dermatomyositis

Case Report and Review of the Literature

Muñoz-Santos C. · Sàbat M. · Sáez A. · Gratacós J. · Luelmo J.
aDermatology Unit and Departments of bPathology and cRheumatology, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell, Spain

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Multicentric reticulohistiocytosis is a rare disorder of unknown etiology, characterized by skin and mucosal papulonodular eruptions and destructive polyarthritis. Histopathological study of these lesions shows a nodular infiltrate composed of histiocytes and multinucleated giant cells, with an eosinophilic, granular, ‘ground-glass’ cytoplasm. We report a case of multicentric reticulohistiocytosis with skin lesions mimicking dermatomyositis and we also review previously reported cases describing such a clinical situation. Our case further emphasizes that multicentric reticulohistiocytosis can mimic clinical features of dermatomyositis. A macular or patch-like erythema in a photodistributed fashion, in addition to other clinical manifestations, can be mistaken for dermatomyositis. However, skin biopsies from these areas may early differentiate both conditions with different treatment options and morbidity.

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