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Multicentric Reticulohistiocytosis-Mimicking Dermatomyositis

Case Report and Review of the Literature Muñoz-Santos C.a · Sàbat M.a · Sáez A.b · Gratacós J.c · Luelmo J.a
aDermatology Unit and Departments of bPathology and cRheumatology, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell, Spain Dermatology 2007;214:268–271 (DOI:10.1159/000099594)


Multicentric reticulohistiocytosis is a rare disorder of unknown etiology, characterized by skin and mucosal papulonodular eruptions and destructive polyarthritis. Histopathological study of these lesions shows a nodular infiltrate composed of histiocytes and multinucleated giant cells, with an eosinophilic, granular, ‘ground-glass’ cytoplasm. We report a case of multicentric reticulohistiocytosis with skin lesions mimicking dermatomyositis and we also review previously reported cases describing such a clinical situation. Our case further emphasizes that multicentric reticulohistiocytosis can mimic clinical features of dermatomyositis. A macular or patch-like erythema in a photodistributed fashion, in addition to other clinical manifestations, can be mistaken for dermatomyositis. However, skin biopsies from these areas may early differentiate both conditions with different treatment options and morbidity.


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