Essential Fatty Acids and Their Long-Chain Polyunsaturated Metabolites in Maternal and Cord Plasma Triglycerides during Late GestationBerghaus T.M. · Demmelmair H. · Koletzko B.
Department of Paediatrics, Ludwig-Maximilians University, Munich, Germany Corresponding Author
Berthold Koletzko, MD, Professor of Paediatrics, Division of Metabolic Disorders and
Nutrition, Kinderklinik and Kinderpoliklinik, Dr. von Haunersches Kinderspital
Klinikum Innenstadt, Ludwig-Maximilians-University of Munich
Lindwurmstrasse 4, D–80337 München (Germany), Tel. +49 89 5160 3967
Fax +49 89 5160 3336, E-Mail firstname.lastname@example.org
The fatty acid composition of plasma lipids was determined in 41 pairs of mothers and their term infants at time of birth (38–42 postmenstrual weeks) by high-resolution capillary gas-liquid chromatography. Linoleic and α-linolenic acids were found at smaller concentrations in cord than in maternal triglycerides, in contrast to strikingly higher proportions of their long-chain polyunsaturated metabolites (LC-PUFA), which indicates a preferential maternofetal transport for certain physiologically important LC-PUFA. While no significant gestational age-dependent changes occurred in maternal plasma triglycerides, the values for most of the fetal long-chain n–3 metabolites increased with the duration of gestation, possibly reflecting an increased transplacental fatty acid passage during late pregnancy or a maturation of desaturation in the fetal liver.
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