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Vol. 77, No. 2, 2000
Issue release date: February 2000
Section title: Original Paper
Biol Neonate 2000;77:96–100
(DOI:10.1159/000014201)

Essential Fatty Acids and Their Long-Chain Polyunsaturated Metabolites in Maternal and Cord Plasma Triglycerides during Late Gestation

Berghaus T.M. · Demmelmair H. · Koletzko B.
Department of Paediatrics, Ludwig-Maximilians University, Munich, Germany
email Corresponding Author

Berthold Koletzko, MD, Professor of Paediatrics, Division of Metabolic Disorders and

Nutrition, Kinderklinik and Kinderpoliklinik, Dr. von Haunersches Kinderspital

Klinikum Innenstadt, Ludwig-Maximilians-University of Munich

Lindwurmstrasse 4, D–80337 München (Germany), Tel. +49 89 5160 3967

Fax +49 89 5160 3336, E-Mail berthold.koletzko@kk-i.med.uni-muenchen.de

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Abstract

The fatty acid composition of plasma lipids was determined in 41 pairs of mothers and their term infants at time of birth (38–42 postmenstrual weeks) by high-resolution capillary gas-liquid chromatography. Linoleic and α-linolenic acids were found at smaller concentrations in cord than in maternal triglycerides, in contrast to strikingly higher proportions of their long-chain polyunsaturated metabolites (LC-PUFA), which indicates a preferential maternofetal transport for certain physiologically important LC-PUFA. While no significant gestational age-dependent changes occurred in maternal plasma triglycerides, the values for most of the fetal long-chain n–3 metabolites increased with the duration of gestation, possibly reflecting an increased transplacental fatty acid passage during late pregnancy or a maturation of desaturation in the fetal liver.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/7/2000

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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