Dementia in Clinical Practice

Editor(s): Giannakopoulos P. (Geneva) 
Hof P.R. (New York, N.Y.) 
Table of Contents
Vol. 24, No. , 2009
Section title: Vascular Dementia
Giannakopoulos P, Hof PR (eds): Dementia in Clinical Practice. Front Neurol Neurosci. Basel, Karger, 2009, vol 24, pp 95–106

Is It Possible to Treat Vascular Dementia?

Zekry D.
Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thônex, Geneva, Switzerland
email Corresponding Author

Dr. Dina Zekry

Hôpital des Trois-Chênes

3, chemin du Pont-Bochet

CH–1226 Thônex, Geneva (Switzerland)

Tel. +41 22 305 6355

Fax +41 22 305 6115


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Randomized controlled trials of primary and secondary prevention of vascular dementia demonstratereal effects on the cause or progression of disease (disease-modifying treatment). These strategieslead to a reduction in all cerebrovascular risk factors, in particular hypertension. Such treatmentmay prevent dementia by reducing stroke and possibly by other mechanisms that remain undetermined,such as those involved in neurodegeneration and cell death. Curative treatment of vasculardementia, particularly given recent studies on cholinesterase inhibitors (rivastigmine, donepezil andgalantamine) and memantine, is still ineffective. There is insufficient evidence to support widespreaduse of these drugs in vascular dementia. Particular considerations should be taken into account inclinical trials. Vascular dementia is a heterogeneous disease with different subtypes and mechanisms.Therefore, well-designed, adequately powered trials accounting for this heterogeneity, withbetter clinical definitions and an assessment and detection of cognitive and global changes specificto vascular dementia, are needed.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Vascular Dementia

Published online: 1/26/2009
Cover Date: 2009

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9015-0 (Print)
eISBN: 978-3-8055-9016-7 (Online)

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