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Vol. 29, No. 2, 2010
Issue release date: January 2010
Section title: Paper
Blood Purif 2010;29:137–144

Phosphate Elimination in Modalities of Hemodialysis and Peritoneal Dialysis

Kuhlmann M.K.
Department of Internal Medicine – Nephrology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
email Corresponding Author

Martin K. Kuhlmann

Vivantes Klinikum im Friedrichshain

Department of Internal Medicine – Nephrology, Landsberger Allee 49,

DE–10249 Berlin (Germany)


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Hyperphosphatemia is highly prevalent in hemodialysis (HD) and peritoneal dialysis (PD) patients and is a major risk factor for cardiovascular mortality. Elimination of inorganic phosphate by dialysis is a cornerstone of the management of hyperphosphatemia. Phosphate clearance during HD is affected by various factors of dialysis prescription, such as blood and dialysate flow rate, dialyzer membrane surface area and ultrafiltration volume. Phosphate mass removal can be improved by hemodiafiltration, increased dialysis frequencies and extended treatment times. Short daily or extended daily or 3 times weekly nocturnal HD allow higher phosphate mass removal and potentially complete discontinuation of phosphate binder medication. In PD, phosphate mass removal appears to be correlated with peritoneal creatinine but not urea clearance. In hyperphosphatemic PD patients, the decision on the optimal PD modality should be based on peritoneal creatinine and ideally also on peritoneal phosphate transport characteristics.

© 2010 S. Karger AG, Basel

Article / Publication Details

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Abstract of Paper

Published online: 1/8/2010

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

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