Journal Mobile Options
Table of Contents
Vol. 56, No. 4, 2012
Issue release date: July–August
Section title: Novel Insights from Clinical Practice
Acta Cytologica 2012;56:463–466
(DOI:10.1159/000335731)

Hairy Cell Leukemia Presenting as a Peripancreatic Mass: Cytomorphology and Radiographic Correlates

Subhawong A.P. · Subhawong T.K. · Ali S.Z.
Departments of aPathology and bRadiology, Johns Hopkins School of Medicine, Baltimore, Md., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 33.00
Account: USD 23.00

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 10/24/2011 10:05:39 AM
Accepted: 12/13/2011
Published online: 7/25/2012

Number of Print Pages: 4
Number of Figures: 4
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Hairy cell leukemia (HCL) usually presents with peripheral cytopenias, diffuse marrow infiltration, and splenomegaly. This chronic lymphoproliferative disorder is not typically associated with lymphadenopathy or mass lesions. We report a case of HCL first treated by splenectomy, followed by several years of interferon therapy. Twenty-five years later, the patient presented with weight loss, fatigue, and a large PET-avid mass surrounding the head of the pancreas. Fine-needle aspiration was pursued to investigate the unusual and infiltrative appearance of the lesion, which was suggestive of another primary malignancy. Cytology smears showed discohesive lymphoid cells with round nuclei and delicate cytoplasmic projections. Flow cytometry confirmed the presence of a clonal B-cell population with bright expression of CD20 as well as CD25 and CD103, diagnostic of HCL. This is the first report of HCL presenting as a peripancreatic mass. The importance of correlation with radiology and clinical history is emphasized when evaluating such lesions.


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 10/24/2011 10:05:39 AM
Accepted: 12/13/2011
Published online: 7/25/2012

Number of Print Pages: 4
Number of Figures: 4
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Summers TA, Jaffe ES: Hairy cell leukemia diagnostic criteria and differential diagnosis. Leuk Lymphoma 2011;52(suppl 2):6–10.

    External Resources

  2. Tadmor T, Polliack A: Unusual clinical manifestations, rare sites of involvement, and the association of other disorders with hairy cell leukemia. Leuk Lymphoma 2011;52(suppl 2):57–61.

    External Resources

  3. Al-Za’abi AM, Boerner SL, Geddie W: Hairy cell leukemia presenting as a discrete liver mass: diagnosis by fine needle aspiration biopsy. Diagn Cytopathol 2008;36:128–132.

    External Resources

  4. Kaw YT, Artymyshyn RL, Schichman SA, Salhany KE: Recurrent hairy cell leukemia presenting as a large mesenteric mass diagnosed by fine needle aspiration cytology: a case report. Acta Cytol 1994,38:267–270.
  5. Moriarty AT, Schwenk GR Jr, Chua G: Splenic fine needle aspiration biopsy in the diagnosis of lymphoreticular diseases: a report of four cases. Acta Cytol 1993;37:191–196.
  6. Pinto RG, Rocha PD, Vernekar JA: Fine needle aspiration of the spleen in hairy cell leukemia: a case report. Acta Cytol 1995;39:777–780.
  7. Goodman GR, Burian C, Koziol JA, Saven A: Extended follow-up of patients with hairy cell leukemia after treatment with cladribine: J Clin Oncol 2003;21:891–896.
  8. Au WY, Klasa RJ, Gallagher R, Le N, Gascoyne RD, Connors JM: Second malignancies in patients with hairy cell leukemia in British Columbia: a 20-year experience. Blood 1998;92:1160–1164.
  9. Emilia G, Luppi M, Gandini G, Bertesi M, Torelli G: Hairy cell leukemia, second cancer and occupational risk. Br J Haematol 1995;78:518.

    External Resources

  10. Bethel KJ, Sharpe RW: Pathology of hairy-cell leukaemia. Best Pract Res Clin Haematol 2003;16:15–31.
  11. Arnalich F, Camacho J, Jimenez C, Lahoz C, Patrón M: Occurrence of immunoblastic B-cell lymphoma in hairy cell leukemia. Cancer 1987;59:161–164.

    External Resources

  12. Downing JR, Grossi CE, Smedberg CT, Burrows PD: Diffuse large cell lymphoma in a patient with hairy cell leukemia: immunoglobulin gene analysis reveals separate clonal origins. Blood 1986;67:739–744.
  13. Lopera GA, Alvarez OA, Lee M: Large cell lymphoma of the colon presenting as a second malignancy in a patient with hairy cell leukemia. J Clin Gastroenterol 1995;21:259–260.
  14. Franssila KO: Coincidental hairy cell leukemia and large cell malignant lymphoma. Arch Pathol Lab Med 1979;103:437–439.
  15. Sanyal R, Remer EM: Radiology of the retroperitoneum: case-based review. AJR Am J Roentgenol 2009;192:S112–S117.

    External Resources

  16. Mercieca J, Matutes E, Moskovic E, MacLennan K, Matthey F, Costello C, Behrens J, Basu S, Roath S, Fairhead S, Flandrin G, Brizard A, Catovsky D: Massive abdominal lymphadenopathy in hairy cell leukaemia: a report of 12 cases. Br J Haematol 1992;82:547–554.