Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six CasesÁlvarez-Rodriguez F.a · Gimeno-Aranguez M.b · López-Varela C.c · González-Peramato P.d · Tortoledo-Bruni A.b · Rodríguez-Costa J.c · Perna C.f · Jiménez-Heffernan J.A.e
Departments of Pathology,aHospital La Zarzuela, bUniversity Hospital Infanta Leonor, cUniversity Hospital Gregorio Marañón, dUniversity Hospital La Paz, and eUniversity Hospital Puerta de Hierro, Madrid, and fUniversity Hospital Guadalajara, Guadalajara, Spain
Correspondence to: Dr. José A. Jiménez-Heffernan
Departamento de Anatomía Patológica, Hospital Universitario Puerta de Hierro
C/Manuel de Falla 1
ES–28022 Majadahonda, Madrid (Spain)
Tel. +34 91 357 3081, E-Mail firstname.lastname@example.org
Do you have an account?
Objective: To evaluate cytologic features of mammary myofibroblastoma in order to establish the possibility of precise preoperative recognition. Study Design: This was a multi-institutional study of 6 patients with myofibroblastoma (5 men and 1 woman) in which preoperatively fine-needle aspiration cytology was performed. Four cases showed classical histologic features, 1 corresponded to the cellular variant and the remaining 1 to the fibrous form. Results: Except for 1 case, smears were cellular and distributed as irregular aggregates and single cells. Most groups showed a small amount of metachromatic stroma and capillaries. Cells retained cytoplasm and showed a spindle-to-plump oval morphology with moderate pleomorphism. Nuclear pleomorphism was present and was relevant in 1 case. Intranuclear pseudoinclusions and mast cells were present in 3 cases. No epithelial clusters were seen. Due to hypercellularity and pleomorphism 1 case was considered as suspicious for malignancy. The remaining 5 were diagnosed as low-grade mesenchymal lesions, and myofibroblastoma was suggested in 3. Conclusion: Cytologic features of myofibroblastoma reflect what is seen on histology. When such findings are correlated with image studies, preoperative recognition can be possible. This is especially true for male patients in whom the tumor is relatively frequent.
© 2012 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.