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Vol. 57, No. 2, 2013
Issue release date: March – April
Section title: Novel Insights from Clinical Practice
Acta Cytologica 2013;57:198–202
(DOI:10.1159/000345900)

Xanthogranuloma of Bone: A Challenging Imitator of Malignancy

Holmes B.J. · Castelino-Prabhu S. · Rosenthal D.L. · Ali S.Z.
Departments of aPathology and bRadiology, The Johns Hopkins Hospital, Baltimore, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 9/4/2012 4:47:21 PM
Accepted: 11/13/2012
Published online: 2/28/2013

Number of Print Pages: 5
Number of Figures: 6
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Xanthogranulomatous disease of bone is exceptionally uncommon. Clinically, radiologically and pathologically, it is a great imitator of malignancy. While there are few reports on the surgical pathology of this rare entity, there is no published report on its cytopathologic characteristics. We report herein the case of a 44-year-old male who was evaluated at The Johns Hopkins Hospital for a 2.3-cm painful soft tissue mass present within the medullary canal of the distal tibia with destruction of the overlying cortex. A computed tomography-guided fine needle aspiration biopsy revealed abundant histiocytes and occasional giant cells in an inflammatory background. This was interpreted as a ‘histiocyte-rich lesion,’ and an excisional biopsy was recommended. Subsequent curettage was performed, and the histological material was diagnosed as ‘xanthogranuloma of bone.’ The rarity of xanthogranuloma of bone and its resemblance to the more common reactive and malignant bone neoplasms may present diagnostic challenges.


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 9/4/2012 4:47:21 PM
Accepted: 11/13/2012
Published online: 2/28/2013

Number of Print Pages: 5
Number of Figures: 6
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

  1. Ladefoged C, Lorentzen M: Xanthogranulomatous cholecystitis. A clinicopathological study of 20 cases and review of the literature. APMIS 1993;101:869–875.
  2. Nistal M, Gonzalez-Peramato P, Serrano A, Regadera J: Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review. Arch Pathol Lab Med 2004;128:911–914.
  3. Oh YH, Seong SS, Jang KS, Chung YW, Paik CH, Park YW, Han DS: Xanthogranulomatous inflammation presenting as a submucosal mass of the sigmoid colon. Pathol Int 2005;55:440–444.
  4. Cuzutto C: Xanthogranulomatous osteomyelitis. Arch Pathol Lab Med 1984;108:973–976.

    External Resources

  5. Golden GN, Richards HG: Xanthogranulomatous disease of bone with polyarthritis: report of 2 cases. J Bone Joint Surg Br 1953;35:275–284.

    External Resources

  6. Vankalakunti M, Saikia UN, Mathew M, Kang M: Xanthogranulomatous osteomyelitis of ulna mimicking neoplasm. World J Surg Oncol 2007;5:46.
  7. Borjian A, Rezaei F, Eshaghi MA, Shemshaki H: Xanthogranulomatous osteomyelitis. J Orthop Traumatol 2011;13:217–220.
  8. Wald ER: Risk factors for osteomyelitis. Am J Med 1985;78:206–212.
  9. Pohar-Marinsek Z, Us-Krasovec M: Cytomorphology of Langerhans cell histiocytosis. Acta Cytol 1996;40:1257–1264.
  10. Scuderi RT, Makani SS, Channick CL, Renner JW, Alexander TH, Brumund KT, Read WL, Weidner N: Pulmonary Langerhans cell histiocytosis diagnosed in a cervical lymph node: a case report. Acta Cytol 2010;4:618–622.
  11. Li S, Yan Z, Jhala N, Jhala D: Fine needle aspiration diagnosis of Rosai-Dorfman disease in an osteolytic lesion of bone. Cytojournal 2010;7:12.
  12. Majumdar K, Tyagi I, Saran RK, Kumar S, Gondal R: Multicentric extranodal Rosai Dorfman disease – a cytological diagnosis, with histological corroboration. Acta Cytol 2012;2:214–218.

    External Resources

  13. Purgina B, Jaffe R, Monaco SE, Khalbuss WE, Beasley HS, Dunn JA, Pantanowitz L: Cytomorphology of Erdheim-Chester disease presenting as a retroperitoneal soft tissue lesion. Cytojournal 2011;8:22.
  14. Ortiz J, Fernandez D, Bullon A: Gaucher’s disease: morphological findings in a case studied with fine needle aspiration. Cytopathology 2002;13:371–374.
  15. Treaba D, Assad L, Govil H, Sariya D, Reddy VB, Kluskens L, Green L, Selvaggi SM, Gattuso P: Diagnostic role of fine-needle aspiration of bone lesions in patients with a previous history of malignancy. Diagn Cytopathol 2002;26:380–383.
  16. Layfield LJ: Cytologic diagnosis of osseous lesions: a review with emphasis on the diagnosis of primary neoplasms of bone. Diagn Cytopathol 2009;37:299–310.
  17. Sathiyamoorthy S, Ali SZ: Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration. Acta Cytol 2012;5:481–486.

    External Resources