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Vol. 57, No. 3, 2013
Issue release date: May – June
Section title: Novel Insights from Clinical Practice
Acta Cytologica 2013;57:309-312
(DOI:10.1159/000348248)

Warthin Tumor with Signet-Ring Cell Features as a Pitfall in Salivary Gland Cytopathology

Bellevicine C. · Iaccarino A. · Malapelle U. · Troncone G.
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy

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Abstract

Background: Warthin tumor (WT) is a common parotid lesion reliably diagnosed by fine-needle aspiration (FNA). Worrisome metaplastic changes may occur in WT. Their interpretation as mucoepidermoid carcinoma represents a diagnostic pitfall. Moreover, WT and mucoepidermoid carcinoma may coexist, making this distinction difficult. So it is worthwhile to report unusual WT features. We describe a WT with signet-ring cells (SRCs). Case: A 61-year-old male presenting with a 3.6-cm right parotid gland mass underwent FNA with rapid on-site evaluation. DiffQuik-stained smears showed groups of oncocytic cells with abundant granular cytoplasm in a background rich with debris, foamy macrophages and lymphoid cells. SRCs were observed on Papanicolaou-stained smears prepared from a second pass. A WT with SRC features was diagnosed. Histology revealed a WT with post-FNA infarctual changes. Conclusion: To avoid false-positive diagnoses, the cytopathologist should be aware that SRC features may occur in WT. The concomitant presence of oncocytes and SRCs is useful to correctly diagnose this unusual WT variant.


Article / Publication Details

Received: 8/6/2012
Accepted: 1/16/2013
Published online: 4/25/2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

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