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Cardiology 2013;125:38-49
(DOI:10.1159/000348871)

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

Mangual J.O.a · Föll D.c · Jung B.c · Pedrizzetti G.b · Kheradvar A.d

Author affiliations

aUniversity of Florence, Florence, and bUniversity of Trieste, Trieste, Italy; cUniversity Hospital Freiburg, Freiburg, Germany; dUniversity of California, Irvine, Calif., USA

Corresponding Author

Arash Kheradvar, MD, PhD, FAHA

The Edwards Lifesciences Center for Advanced Cardiovascular Technology

Department of Biomedical Engineering, University of California, Irvine

2410 Engineering Hall, Irvine, CA 92697 (USA)

E-Mail arashkh@uci.edu

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Abstract

Objectives: This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. Methods: Previous studies suggest that aging remarkably influences regional myocardial motion, mostly myocardial velocities in both radial and long-axis directions. However, the effect of aging on cardiac viscoelasticity, which exhibits time-dependent strain, has not been elucidated yet. In this study, myocardial velocity and displacement mapping of the LV was performed using TPM in 39 healthy subjects divided into three age groups. The viscoelasticity parameters were obtained for each segment of the LV and compared among the studied groups. Results: The analyses showed that myocardial elasticity ranged from approximately 20 to -20 dyne/cm2 during a cardiac cycle, and the myocardial viscous-damping component ranged from -1 to 1 dyne × s/cm2. Overall, no statistically significant difference was observed in the viscoelasticity components among the subjects in the different age groups (p > 0.05). Conclusion: Myocardial viscoelastic behavior of the LV in radial direction was found to be considerably similar in pattern and magnitude among the studied subjects of different age groups with no statistically significant difference, despite the fact that the regional myocardial velocities change due to aging.

© 2013 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: December 31, 2012
Accepted: February 06, 2013
Published online: April 30, 2013

Number of Print Pages: 12
Number of Figures: 4
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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