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Vol. 58, No. 1, 2014
Issue release date: January–February
Section title: Gynecologic Cytopathology
Acta Cytologica 2014;58:47-52
(DOI:10.1159/000356988)

Correlation Discrepancies between High-Grade Squamous Intraepithelial Lesions and High-Grade Cervical Intraepithelial Neoplasia: A Cytological/Histological Correlation Study from a Single-Institution Experience

Zhang M. · Carrozza M. · Huang Y.
aDepartment of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, Pa., and bDivision of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn., USA

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Article / Publication Details

First-Page Preview
Abstract of Gynecologic Cytopathology

Received: 6/18/2013 12:09:23 PM
Accepted: 10/31/2013
Published online: 12/10/2013

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Objective: Previous studies have demonstrated diagnostic discrepancies for the detection of high-grade cervical intraepithelial neoplasia (CIN 2/3) from previously confirmed cytological high-grade squamous intraepithelial lesions (HSILs). The goal of this study is to investigate the possible factors which may be responsible for this diagnostic discrepancy. Study Design: The study included all the cytological specimens diagnosed with a HSIL by the Papanicolaou (Pap) test at Temple University Hospital (2000-2010) as well as timely follow-up cervical biopsies. The biopsy tissue types and diagnoses were subsequently categorized and analyzed. Results: Of the total 842 Pap tests with HSIL diagnosis, 96 cases (11.4%) showed non-CIN 2/3 in follow-up cervical biopsies. Among those cases, the most common biopsy diagnoses were cervicitis (27.9%) and CIN 1 (25%). Endocervical curettage (ECC) samples showed a high percentage of inadequacy for diagnosis (43.7%). Thirty-seven cases had subsequent follow-up biopsy, and CIN 2/3 was found in 15 cases. However, none of the CIN 2/3 cases was detected by ECC sampling. Conclusions: Our study indicated that the discrepant correlation between HSIL and CIN 2/3 was most likely due to tissue sampling issues during colposcopic examination. The diagnostic value of ECC remains poor for the detection and grading of cervical intraepithelial dysplasia.


Article / Publication Details

First-Page Preview
Abstract of Gynecologic Cytopathology

Received: 6/18/2013 12:09:23 PM
Accepted: 10/31/2013
Published online: 12/10/2013

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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