Cytokines are involved in hematopoiesis and cell growth regulation. Many cytokines have the property of increasing the number of hematopoietic progenitor cells circulating in peripheral blood. Since it has been shown that peripheral blood progenitor support after myeloablative therapy resulted in a faster engraftment than after autologous bone marrow support, recent effort is focusing on optimizing stem cell harvest by different cytokines, cytokine combination, or evaluation of dose and schedule dependencies. One of the first cytokines shown to mobilize stem cells within peripheral blood was the granulocyte-stimulating factor (G-CSF). This review is focusing on the current state of cytokine-induced mobilization of stem cells in patients with hematological malignancies or solid tumors.

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1999
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