Immune Response and the Eye

Editor(s): Niederkorn J.Y. (Dallas, Tex.) 
Kaplan H.J. (Louisville, Ky.) 
Table of Contents
Vol. 92, No. , 2007
Section title: Paper
Niederkorn JY, Kaplan HJ (eds): Immune Response and the Eye. Chem Immunol Allergy. Basel, Karger, 2007, vol 92, pp 244-253

Acute Retinal Necrosis

Kezuka T.a · Atherton S.b
aDepartment of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan; bDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Ga., USA

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Acute retinal necrosis (ARN) is a rare disease that is usually caused by one of the three neurotropic human herpesviruses - herpes simplex virus type 1(HSV-1), HSV-2 and varicella-zoster virus (VZV). Although much is known about the clinical course of the disease and its treatment and about the viruses that cause it, comparatively little is known about its pathogenesis. This article will review the history of ARN, the typical clinical findings, and methods of diagnosis. Information from studies of the mouse model of ARN including development of anterior chamber-associated immune deviation (ACAID) and routes of spread will be reconsidered, and the combined information from human and mouse studies will be discussed to suggest mechanisms that contribute to the pathogenesis of ARN in human patients. Finally, puzzles and questions about the disease will be considered.

Article / Publication Details

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Abstract of Paper

Published online: 1/30/2007
Cover Date: 2007

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8187-5 (Print)
eISBN: 978-3-318-01404-4 (Online)

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