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Cover

Status: available   
Publication year: 2006

Genome and Disease

Editor(s): Volff J.-N. (Würzburg) 

Price for personal customers
Online Price: CHF 317.00, EUR 296.00, USD 373.00
Print Price: CHF 317.00, EUR 296.00, USD 373.00
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This book belongs to
Genome Dynamics , Vol. 1
Editor(s): Schmid M. (Würzburg) 
VIII + 246 p., 24 fig., 10 in color, 14 tab., hard cover, 2006
Status: available   
ISSN: 1660-9263
e-ISSN: 1662-3797

First volume of the new book series Genome Dynamics
Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important ‘caretaker’ genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume.
This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.

Bibliographic Details

Genome Dynamics, Vol. 1
Genome and Disease
Editor(s): Volff J.-N. (Würzburg) 
VIII + 246 p., 24 fig., 10 in color, 14 tab., hard cover, 2006
Status: available   
ISBN: 978-3-8055-8029-8
e-ISBN: 978-3-318-01290-3
DOI: 10.1159/isbn.978-3-318-01290-3