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Status: available   
Publication year: 2007

Mechanisms of Dietary Restriction in Aging and Disease

Editor(s): Mobbs C.V. (New York, N.Y.) 
Yen K. (New York, N.Y.) 
Hof P.R. (New York, N.Y.) 


This book belongs to
Interdisciplinary Topics in Gerontology , Vol. 35
Editor(s): Fulop T. (Sherbrooke, Que.) 
VIII + 198 p., 23 fig., 5 tab., hard cover, 2007
Status: available   
ISSN: 0074-1132
e-ISSN: 1662-3800

Read the Reviews

Preface (Free PDF, 35 KB)

T.E. Morgan, A.M. Wong, C.E. Finch: Anti-Inflammatory Mechanisms of Dietary Restriction in Slowing Aging Processes (Free Excerpt, 162 KB)

Giulio Maria Pasinetti, et al.: Caloric Intake and Alzheimer’s Disease. Experimental Approaches and Therapeutic Implications (Free Excerpt, 61 KB)

Dietary interventions to expand lifespan
Dietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the National Institute of Aging convened a program involving several leading gerontological laboratories. Results from many of these, as well as from other leading research institutions in the field, are presented in this book. The first three papers address general molecular mechanisms, derived in part from recent DNA microarray studies, that may mediate protective effects of dietary restriction. The subsequent articles examine specific model systems, including flies, nematodes and non-human primates, that have provided exciting new information about these mechanisms. Finally, mechanisms of dietary restriction mediating protective effects against cancer and neurological diseases are discussed.
In addition to gerontologists and geriatricians, many other medical and nonmedical professionals in the field will find a great wealth of information on possible interventions that may ameliorate age-related diseases.

Bibliographic Details

Interdisciplinary Topics in Gerontology, Vol. 35
Mechanisms of Dietary Restriction in Aging and Disease
Editor(s): Mobbs C.V. (New York, N.Y.) 
Yen K. (New York, N.Y.) 
Hof P.R. (New York, N.Y.) 
VIII + 198 p., 23 fig., 5 tab., hard cover, 2007
Status: available   
ISBN: 978-3-8055-8170-7
e-ISBN: 978-3-318-01390-0