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Original Article

Is Pentraxin 3 a New Cardiovascular Risk Marker in Polycystic Ovary Syndrome?

Sari U.a · Kaygusuz I.b · Kafali H.c

Author affiliations

aDepartment of Obstetrics and Gynecology, Acibadem Levent Medical Center, Istanbul, bDepartment of Obstetrics and Gynecology, Turgut Ozal University Medical School, and cDepartment of Obstetrics and Gynecology, Gazi University Medical School, Ankara, Turkey

Related Articles for ""

Gynecol Obstet Invest 2014;78:173-178

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: May 27, 2013
Accepted: May 18, 2014
Published online: July 09, 2014
Issue release date: September 2014

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Background/Aims: Polycystic ovary syndrome (PCOS) patients have an increased rate of subclinical inflammation, which plays a role in the pathogenesis of atherosclerosis. Pentraxin 3 (PTX3) is an inflammatory mediator which belongs to the same family as the well-established cardiovascular biomarker C-reactive protein (CRP). The present study was performed to investigate plasma PTX3 levels in patients with PCOS and to determine the relationship between PTX3 and other known cardiovascular risk factors. Methods: 40 patients with PCOS and 40 age- and BMI-matched healthy controls were included in the study. The groups were divided into subgroups according to BMI. Insulin resistance indexes, lipid profile, CRP and PTX3 levels were analyzed. Results: There was no difference for insulin resistance indexes and lipid profile between the PCOS and control groups. CRP levels were significantly higher in obese PCOS and control subjects than in lean subjects, whereas no difference in PTX3 concentrations was observed between subgroups. Conclusion: PTX3 and CRP levels were similar in the PCOS group compared with the non-PCOS control group.

© 2014 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: May 27, 2013
Accepted: May 18, 2014
Published online: July 09, 2014
Issue release date: September 2014

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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