Original Research Article
Cognitive Changes in Parkinson’s Disease Patients with Visual HallucinationsRamirez-Ruiz B.a, b · Junque C.a, b · Marti M.-J.a, c · Valldeoriola F.a, c · Tolosa E.a, c
aInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), bDepartment of Psychiatry and Clinical Psychobiology, University of Barcelona, cParkinson’s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic Universitari, University of Barcelona, Barcelona, Spain
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Objective: To evaluate the decline in specific neuropsychological functions in nondemented Parkinson’s disease (PD) patients with a history of visual hallucinations (VH). Methods: Twenty PD patients with VH, 20 PD patients without VH and 18 normal controls were followed up over a 1-year period and assessed for cognitive decline. Results: Forty-five percent of nondemented hallucinating PD patients developed dementia during the 1-year period between baseline and follow-up evaluations. Of the nondemented hallucinating PD patients nearly 70% showed impairment in multiple cognitive domains. The progressive decline in hallucinating PD patients affected mainly visual memory for faces and visuoperceptive-visuospatial functions. Conclusion: Our results support a fast impairment of complex visual functions in hallucinating PD patients, but also a progressive decline in multiple cognitive domains, which have been identified as a risk of developing dementia in PD.
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