Oncology Research and Treatment

Review Article · Übersichtsarbeit

Do the Results of the New Trials Change the Standard Treatment of Metastatic Renal Cell Cancer?

Mulder S.F. · Spronsen D.J. · Mulder P.H.M.

Author affiliations

Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands

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Onkologie 2007;30:260-264

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Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: April 25, 2007
Issue release date: May 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT

Abstract

With the emergence of novel angiogenesis inhibitors, we are moving to a new era for patients with metastasized renal cell carcinoma. Since the results achieved reflect more a modification of the natural course of the disease than a cure, past achievements should not be neglected. Low-risk patients with clear cell histology, especially those with pulmonary metastasis only, should still be offered cytokine therapy. For intermediate-risk patients sunitinib is the treatment of choice. For high-risk patients, temsirolimus has to date provided the most convincing data, its availability is however limited. Data with sorafenib and sunitinib in the high-risk group are still anecdotal. The toxicity profiles of these 2 drugs are different and might particularly relate to patients with known cardiovascular co-morbidity. No sufficient data are available regarding sequential use. After cytokine failure, sorafinib is the treatment of choice. Patients should preferably be treated within clinical trials to answer unaddressed questions. It is well known that the strict entry criteria used within the clinical studies were applied very flexibly when drugs have been approved. These aspects require a careful follow-up to ascertain optimal use and to prevent misuse. Finally, the costs of prolonged treatment will be enormous, and only meaningful survival advantages will convince the health authorities to make these new treatments available for all patients.




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Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: April 25, 2007
Issue release date: May 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT


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