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Review

Classification of Ph-Negative Chronic Myeloproliferative Disorders – Morphology as the Yardstick of Classification

Kvasnicka H.M. · Thiele J.

Author affiliations

Institute of Pathology, University of Cologne, Cologne, Germany

Corresponding Author

Hans Michael Kvasnicka, MD

Institute for Pathology, University of Cologne

Joseph-Stelzmann-Strasse 9

DE–50924 Cologne (Germany)

Tel. +49 221 47 86369, Fax +49 221 47 86360, E-Mail hm.kvasnicka@uni-koeln.de

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Pathobiology 2007;74:63–71

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Abstract

Objective: Histopathology of bone marrow (BM) biopsies plays a crucial role in the interdisciplinary approach to diagnosis and classification of Ph-negative chronic myeloproliferative disorders. Based on careful clinicopathologic studies, BM features are critical determinants that help to predict overall prognosis, to detect complications such as progression to myelofibrosis and blast crisis, and to assess therapy-related changes. Methods and Results: A systematic evaluation of BM histopathology allows an objective identification of cases of (true) essential thrombocythemia and their separation from early prefibrotic stages of chronic idiopathic myelofibrosis. By follow-up examinations that include BM biopsies, the progression of the disease process is unveiled, which is especially important for patients with initial polycythemia vera and prefibrotic chronic idiopathic myelofibrosis that may require a different therapeutic approach than the full-blown stages. Conclusion: BM biopsy should be considered as major diagnostic tool for evaluation and follow-up of patients enrolled in prospective studies.

© 2007 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Received: March 05, 2007
Accepted: March 27, 2007
Published online: June 25, 2007
Issue release date: June 2007

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: https://www.karger.com/PAT


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