Original Report: Patient-Oriented, Translational Research
Kidney Function and Sarcopenia in the United States General Population: NHANES IIIFoley R.N.a, b · Wang C.a · Ishani A.a, b · Collins A.J.a, b · Murray A.M.a, c
aUnited States Renal Data System Coordinating Center, bDepartment of Medicine, University of Minnesota, and cDepartment of Medicine, Hennepin County Medical Center, Minneapolis, Minn., USA
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Background/Aims: It is not known whether sarcopenia is associated with levels of kidney function in community-dwelling adults. Methods: Subjects were adult Third National Health and Nutrition Examination Survey participants in whom bioimpedance was performed (n = 13,770). Class I sarcopenia was defined as a skeletal mass index of 1–2 standard deviations below and class II sarcopenia as <2 standard deviations below young adult values. Results: A monotonic association existed between increasing sarcopenia prevalence and declining glomerular filtration rate: ≧90 ml/min/1.73 m2, 22.8% class I, 3.8% class II sarcopenia; 60–89 ml/min/1.73 m2, 33.6% class I, 5.3% class II sarcopenia, and <60 ml/min/1.73 m2, 50.7% class I, 9.4% class II sarcopenia (p < 0.0001). This association dissipated when adjustment was made for older age and more comorbidity. Multivariate associations (p < 0.05) of sarcopenia and chronic kidney disease included: older age; low income-to-poverty ratio; overweight; lack of exercise; low carbohydrate, fat and protein intake; hypercalcemia; low 25-hydroxy-vitamin D3; higher diastolic blood pressure, and insulin resistance. Conclusion: Sarcopenia is common in community-dwelling adults with chronic kidney disease. Although causality cannot be assumed, several associations may be susceptible to intervention.
© 2007 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.