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BACE1 Expression and Activity: Relevance in Alzheimer’s Disease

Zacchetti D.a, b · Chieregatti E.a, b · Bettegazzi B.a · Mihailovich M.a · Sousa V.L.a · Grohovaz F.a, b · Meldolesi J.a, b

Author affiliations

aVita-Salute San Raffaele University and San Raffaele Scientific Institute, and bIIT Research Unit of Molecular Neuroscience, Milano, Italy

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Neurodegenerative Dis 2007;4:117–126

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: August 08, 2006
Accepted: December 12, 2006
Published online: June 29, 2007
Issue release date: June 2007

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD

Abstract

A turning point of research in Alzheimer’s disease was undoubtedly the discovery of BACE1, the amyloid-β precursor protein-cleaving enzyme that initiates the generation of amyloid-β, the peptide strongly suspected to be responsible for neuronal malfunction and death. Several research groups started a race to identify the best inhibitor of BACE1 activity. On the other hand, basic researchers are evaluating the changes in BACE1 expression and activity with the aim to better understand the pathogenetic process of the disease. Along this second line of research, in the last few years many important results have been reported in various experimental models, as well as in Alzheimer’s disease patients. As a consequence, new pathogenetic paradigms have been developed. We have reviewed these reports trying to highlight contrasting viewpoints, data awaiting final confirmation, and promising perspectives.

© 2007 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: August 08, 2006
Accepted: December 12, 2006
Published online: June 29, 2007
Issue release date: June 2007

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD


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