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Clinical and Laboratory Investigations

Role of Depression in Quality of Life for Patients with Psoriasis

Schmitt J.M.a, d · Ford D.E.a-c

Author affiliations

aDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and Departments of bMedicine and cPsychiatry, Johns Hopkins University, Baltimore, Md., USA; dDepartment of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

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Dermatology 2007;215:17–27

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Published online: June 21, 2007
Issue release date: June 2007

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 6

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: It has been proposed that depression plays a role in how psoriasis affects quality of life. However, primary data are limited. Objective: To investigate the role depression plays in how patients experience psoriasis. Methods: Cross-sectional study conducted between January and May 2005. Recruitment of 265 adults with prevalent psoriasis through Internet advertisements. Standardized assessment of depressive symptoms, health-related quality of life (HRQL), illness-related stress, and clinical severity of psoriasis using validated scales. Results: Thirty-two percent of all participants screened positive for depression. We observed a graded relationship between depressive symptoms and HRQL impairment (p < 0.001). Only 16.5% of those with high depression scores were currently treated for depression. Both dissatisfaction with antipsoriatic treatment and illness-related stress were highly associated with depression. After adjustment for HRQL, patients with more severe psoriasis were less likely depressed, although this association failed to reach statistical significance (multiadjusted odds ratio 0.37; 95% CI 0.13–1.02; p = 0.06). Conclusion: Patients with high subjective distress and low objective measures of psoriasis should be evaluated for depression.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Published online: June 21, 2007
Issue release date: June 2007

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 6

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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