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Pharmacology and Treatment

Infliximab for the Treatment of Hidradenitis Suppurativa

Fernández-Vozmediano J.M. · Armario-Hita J.C.

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Department of Dermatology, University Hospital of Puerto Real, University of Cádiz, Cádiz, Spain

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Dermatology 2007;215:41–44

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: September 25, 2006
Accepted: February 27, 2007
Published online: June 21, 2007
Issue release date: June 2007

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Introduction: Hidradenitis suppurativa is a chronic inflammatory disease characterized by significant morbidity. Current medical therapies are usually only minimally effective. Objective: To assess the efficacy and safety of infliximab monotherapy for the treatment of severe extensive refractory forms of hidradenitis suppurativa. Design: A retrospective study in a group of 6 patients who received treatment with infliximab for hidradenitis suppurativa, in the Dermatology Department of the University Hospital of Puerto Real in the last year. The dose was 5–10 mg/kg at weeks 0, 2 and 6, followed by a maintenance dose every 4 weeks. Subjective and objective efficacy was assessed before and after each treatment session. Results: All patients experienced improvement in subjective symptoms after the initial dose. A decrease in exudation, the size and number of lesions and less development of fistulous tracts were observed. The patients were followed up during 6 months. Treatment was generally well tolerated and there was only one mild reaction to the infusion in the form of headache. No patient required treatment discontinuation due to adverse effects. Conclusions: Infliximab was shown to be an effective therapeutic alternative for severe extensive forms of hidradenitis suppurativa when it is used as monotherapy.

© 2007 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: September 25, 2006
Accepted: February 27, 2007
Published online: June 21, 2007
Issue release date: June 2007

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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