Acute Kidney Injury
Editor(s): Ronco, C. (Vicenza)Bellomo, R. (Melbourne, VIC)
Kellum, J.A. (Pittsburgh, PA)
Continuous Renal Replacement in Critical IllnessRonco C.a · Cruz D.a · Bellomo R.baDepartment of Nephrology, San Bortolo Hospital, Vicenza, Italy;
bDepartment of Intensive Care, Austin Hospital, Melbourne, Vic., Australia
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Article / Publication Details
Published online: April 25, 2007
Cover Date: 2007
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8271-1 (Print)
eISBN: 978-3-318-01456-3 (Online)
Abstract
Acute renal failure in the intensive care unit is usually part of the multiple organ dysfunction syndrome, and the complexity of illness in patients with this complication has risen in recent years. Continuous renal replacement therapy (CRRT) was introduced in the late 1970s and early 1980s to compensate for the inadequacies of conventional intermittent hemodialysis (IHD) in the treatment of these patients. IHD was considered aggressive and unphysiological, often resulting in hemodynamic intolerance and limited efficiency. Although CRRT has been shown to be physiologically superior with respect to IHD in both observational and randomized studies, it is not clear whether this physiological superiority translates into clinically important gains. A number of recent studies have tried to address this issue, and with these, there is a lack of evidence to suggest improved survival and major clinical outcomes with CRRT. However, these studies are generally underpowered and have certain aspects which may influence the interpretation of their results. In addition, the development of hybrid techniques, such as slow extended daily dialysis, makes this a dynamic area of study where the terms of comparison are constantly changing. This article reviews recent trials comparing CRRT and IHD, and discusses their results and limitations.
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Article / Publication Details
Published online: April 25, 2007
Cover Date: 2007
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8271-1 (Print)
eISBN: 978-3-318-01456-3 (Online)
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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