European Neurology

Original Paper

Can We Talk about CD4+CD28– Lymphocytes as a Risk Factor for Ischemic Stroke?

Nowik M.a · Nowacki P.a · Grabarek J.b · Drechsler H.a · Białecka M.c · Widecka K.d · Stankiewicz J.f · Safranow K.e

Author affiliations

Departments of aNeurology, bPathomorphology, cPharmacokinetics and Therapeutic Drug Monitoring, dEndocrinology, Arterial Hypertension and Metabolic Diseases and eBiochemistry and Medical Chemistry, Pomeranian Medical University, and fDepartment of Neurology, Central Provincial Hospital, Szczecin, Poland

Keywords: Inflammatory factorsCD4+CD28– lymphocytesAcute ischemic stroke

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Eur Neurol 2007;58:26–33
https://doi.org/10.1159/000102163

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 12, 2006
Accepted: December 06, 2006
Published online: May 04, 2007
Issue release date: July 2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Background: CD4+CD28– lymphocytes are implicated in the destabilization of atheromatous plaque, leading to acute coronary episodes. One may ask whether these cells play a similar role in ischemic stroke pathogenesis with an atherosclerotic background. Methods: Flow cytometry was applied to determine the percentage of CD4+CD28– lymphocytes in the peripheral blood of patients during the acute phase of their first ischemic stroke (group I) and in patients without a history of stroke but with two of the most important risk factors (hypertension, diabetes) for atherosclerosis-related ischemic stroke (group II). The results were compared with healthy controls. Results: The median percentages of CD4+CD28– lymphocytes in groups I and II did not differ significantly, but for each of these groups the percentage was higher than in the control group. The time of blood sampling from onset of stroke, presence of the ischemic focus in the CT brain scan and severity of neurological deficits did not correlate with the percentage of CD4+CD28– lymphocytes. Conclusions: We conclude that CD4+CD28– lymphocytes are implicated in mechanisms enhancing the risk of acute ischemic stroke and not a consequence of stroke.

© 2007 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 12, 2006
Accepted: December 06, 2006
Published online: May 04, 2007
Issue release date: July 2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

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2007, Vol.58, No. 1

July 2007

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