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Review Article

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Is Antioxidant Therapy a Viable Alternative for Mild Cognitive Impairment? Examination of the Evidence

Ancelin M.-L.a · Christen Y.b · Ritchie K.a

Author affiliations

aInserm, U888, University of Montpellier-1, Montpellier, and bIpsen, Paris, France

Corresponding Author

Dr. Yves Christen

24 rue Erlanger

FR–75016 Paris (France)

Tel. +33 144 96 1010, Fax +33 144 96 1199 E-Mail yves.christen@ipsen.com

Related Articles for ""

Dement Geriatr Cogn Disord 2007;24:1–19

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Therapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on the part of drug regulators to instigate preventive pharmacotherapies. In this context, antioxidant therapies may provide a low-risk alternative, targeting very early biological changes. While a growing body of knowledge demonstrates both the importance of oxidative stress in the aetiology of dementia and the efficacy of antioxidant treatment in animal and cellular models, studies in humans are presently inconclusive. While some antioxidants, notably flavonoid- or vitamin-rich diets, appear to lower the relative risk for Alzheimer’s disease in humans in observational studies, these results must be interpreted in the light of the biological complexity of the relationship between oxidative stress and neurodegeneration, and the methodological and theoretical shortcomings of studies conducted to date. A clearer understanding of these factors will assist in the interpretation of the results of the intervention studies which are now being undertaken; these studies being the only current means of establishing efficacy for preventive drug treatment of Alzheimer’s disease.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review Article

Received: September 25, 2006
Accepted: January 18, 2007
Published online: May 10, 2007
Issue release date: June 2007

Number of Print Pages: 19
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

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