Gynecologic and Obstetric Investigation
Original Paper
Placental Apoptosis in Normal and Abnormal PregnanciesHalperin R.a · Peller S.b · Rotschild M.b · Bukovsky I.a · Schneider D.aDepartments of aObstetrics and Gynecology and bHematology, Assaf Harofe Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel
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Article / Publication Details
Published online: August 16, 2000
Issue release date: August 2000
Number of Print Pages: 4
Number of Figures: 4
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
The aim of this study was to demonstrate apoptosis in the human placenta in normal and abnormal pregnancies. The percentage of apoptotic cells in placental samples was quantified by analyzing the cell cycle of nuclei stained with propidium iodide using a flow cytometer. No significant difference in the percentage of apoptotic cells was obseved comparing the group of normal pregnancies (first and second trimesters) with those of missed abortions. There was also no difference in the incidence of apoptosis comparing placental samples obtained from chromosomally normal and abnormal pregnancies. Yet, there was a significant increase in the incidence of apoptosis in placental samples obtained from second and third trimesters as compared with those obtained from the first trimester (p < 0.04 and p < 0.01, respectively). There was also a significant increase in the incidence of placental apoptosis in the third as compared with the second trimester (p < 0.03).
© 2000 S. Karger AG, Basel
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Article / Publication Details
Published online: August 16, 2000
Issue release date: August 2000
Number of Print Pages: 4
Number of Figures: 4
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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