Gynecologic and Obstetric Investigation
Original Paper
Methylenetetrahydrofolate Reductase Polymorphisms Are Not a Risk Factor for Pre-Eclampsia/Eclampsia in Australian WomenKaiser T. · Brennecke S.P. · Moses E.K.Department of Perinatal Medicine and University of Melbourne, Department of Obstetrics and Gynaecology,The Royal Women’s Hospital, Carlton, Vic., Australia
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Gynecol Obstet Invest 2000;50:100–102
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Article / Publication Details
First-Page Preview
Published online: August 16, 2000
Issue release date: August 2000
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 2
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
In European and Japanese but not in Australian, American, and South African women, the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism has been reported to be a genetic risk factor pre-eclampsia/eclampsia (PE/E). The recently described A1298C MTHFR gene polymorphism also results in reduced MTHFR enzyme activity, although to a lesser extent than the previously described C677T polymorphism. Heterozygotes for both polymorphisms are reported to have an even lower MTHFR enzymatic activity than seen in homozygotes for the C677T genotype. In this current study we determined the allele frequency of the A1298C MTHFR gene polymorphism in an Australian population and examined this polymorphism alone and in combination with the C677T MTHFR polymorphism for an association with PE/E. Neither the A1298C polymorphism alone nor a combination of both polymorphisms showed an association with PE/E in our population of Australian women.
© 2000 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Published online: August 16, 2000
Issue release date: August 2000
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 2
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
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