Skin Pharmacology and Physiology

Original Paper

In vivo Assessment of Ectoin: A Randomized, Vehicle-Controlled Clinical Trial

Heinrich U. · Garbe B. · Tronnier H.

Author affiliations

Institute of Experimental Dermatology, University of Witten/Herdecke, Witten, Germany

Keywords: Skin ageingSkin surfaceEctoin efficacyIn vivo assessment

Related Articles for ""
Skin Pharmacol Physiol 2007;20:211–218
https://doi.org/10.1159/000103204

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 21, 2006
Accepted: April 02, 2007
Published online: May 23, 2007
Issue release date: June 2007

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 4

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

Abstract

The aim of the study was to assess an Ectoin formulation with regard to the antiageing properties. The study was designed as a monocentric, randomized, double-blind application test, in order to ensure the compatibility and the efficacy of Ectoin in comparison to a vehicle emulsion. A total of 104 voluntary healthy female test subjects were included in the study. Moisturizing properties as well as other parameters of skin ageing, like skin surface structure and skin elasticity, were determined for treatment A (vehicle) and treatment B (with 2% Ectoin) versus an untreated control. Statistical evaluations according to the Wilcoxon rank-sum test indicate a general preference for the Ectoin treatment by the test subjects in both the application and the efficacy tests. None of the participating test subjects had any side effects throughout the study. In terms of antiageing properties, previous in vitro studies could be confirmed by this clinical trial, clarifying that the natural cell protection concept of Ectoin is transferable to skin care with manifold benefits.

© 2007 S. Karger AG, Basel



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References

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 21, 2006
Accepted: April 02, 2007
Published online: May 23, 2007
Issue release date: June 2007

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 4

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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2007, Vol.20, No. 4

June 2007

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