Gynecologic and Obstetric Investigation
Original Paper
Changes in Plasma Soluble CD26 and CD30 during Pregnancy: Markers of Th1/Th2 Balance?Hoshimoto K.a · Ohta N.a · Ohkura T.a · Inaba N.baDepartment of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, and bDepartment of Obstetrics and Gynecology, Dokkyo University School of Medicine, Tochigi, Japan
|
|
Gynecol Obstet Invest 2000;50:260–263
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication Details
First-Page Preview
Published online: November 17, 2000
Issue release date: November 2000
Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Abstract
The theory that the Th1 and Th2 cell ratio shifts towards Th2 dominance during pregnancy may improve fetal survival has gained support from recent studies. Also, the variation in the Th1/Th2 cell ratio is reportedly associated with intrauterine growth retardation and preeclampsia. On the basis of these findings, the analysis of the Th1/Th2 balance may be useful in predicting severe complications during pregnancy. However, simple methods for the analysis of Th1/Th2 balance are presently not available. Recently, it has been reported that regulation of CD26 cell surface expression correlates with the production of Th1-like cytokines. On the other hand, previous studies proposed that the sCD30 molecule is an activation marker useful for evaluation of a Th2 immune response. It is, therefore, possible that the analysis of the Th1/Th2 balance during pregnancy by measuring plasma sCD26 and sCD30 simultaneously is a simple and useful method. We herein demonstrate that combined analysis of sCD26 and sCD30 is a potent surrogate tool to evaluate the Th1/Th2 balance during pregnancy.
© 2000 S. Karger AG, Basel
Related Articles:
References
- Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG: Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 1993;151:4562–4573.
- Dudley DJ, Chen CL, Mitchell MD, Daynes RA, Araneo BA: Adaptive immune responses during murine pregnancy: Pregnancy-induced regulation of lymphokine production by activated T lymphocytes. Am J Obstet Gynecol 1993;168:1155–1163.
- Hill JA, Polgar K, Anderson DJ: T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 1995;273:1933–1936.
- Mosmann TR, Coffman RL: Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 1989;46:111–147.
- Cher DJ, Mosmann TR: Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol 1987;138:3688–3694.
- Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytocine production by Th1 clones. J Exp Med 1989;170:2081–2095.
- Morimoto C, Torimoto Y, Levinson G, Rudd CE, Schrieber M, Dang NH, Letvin NL, Schlossman SF: 1F7, a novel cell surface molecule, involved in helper function of CD4 cells. J Immunol 1989;143:3430–3439.
- Willheim M, Ebner C, Baier K, Kern W, Schrattbauer K, Thien R, Kraft D, Breiteneder H, Reinisch W, Scheiner O: Cell surface characterization of T lymphocytes and allergen-specific T cell clones: Correlation of CD26 expression with T(H1) subsets. J Allergy Clin Immunol 1997;100:348–355.
- Scheel-Toellner D, Richter E, Toellner KM, Reiling N, Wacker HH, Flad HD, Gerdes J: CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma. Lab Invest 1995;73:685–690.
- Tanaka T, Duke-Cohan JS, Kameoka J, Yaron A, Lee I, Schlossman SF, Morimoto C: Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV. Proc Natl Acad Sci USA 1994;91:3082–3086.
- Durkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H: Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin’s disease. Cell 1992;68:421–427.
- Del Prete G, De Carli M, Almerigogna F, Daniel CK, D’Elios MM, Zancuoghi G, Vinante F, Pizzolo G, Romagnani S: Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. FASEB J 1995;9:81–86.
- Romagnani S, Del Prete G, Maggi E, Chilosi M, Caligaris-Cappio F, Pizzolo G: CD30 and type 2 T helper (Th2) responses. J Leukoc Biol 1995;57:726–730.
-
Del Prete G, Maggi E, Pizzolo G, Romagnani S: CD30, Th2 cytokines and HIV infection: A complex and fascinating link. Immunol Today 1995;16:78–80.
- Chilosi M, Facchetti F, Notarangelo LD, Romagnani S, Del Prete G, Almerigogna F, De Carli M, Pizzolo G: CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn’s syndrome: Evidence for a T helper 2-mediated condition. Eur J Immunol 1996;26:329–334.
- Da Silva JA, Spector TD: The role of pregnancy in the course and aetiology of rheumatoid arthritis. Clin Rheumatol 1992;11:189–194.
- Varner MW: Autoimmune disorders and pregnancy. Semin Perinatol 1991;15:238–250.
- Minkoff H, Nanda D, Menez R, Fikrig S: Pregnancies resulting in infants with acquired immunodeficiency syndrome or AIDS-related complex: Follow-up of mothers, children, and subsequently born siblings. Obstet Gynecol 1987;69:288–291.
- Weber DJ, Wolfson JS, Swartz MN, Hooper DC: Pasteurella multocida infections. Report of 34 cases and review of the literature. Medicine (Baltimore) 1984;63:133–154.
-
Watkinson M, Rushton DI: Plasmodial pigmentation of placenta and outcome of pregnancy in West African mothers. Br Med J 1983;287:251–254.
- Luft BJ, Remington JS: Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice. Infect Immun 1982;38:1164–1171.
- Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP: Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications. Proc Assoc Am Physicians 1996;108:374–381.
- Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti R, Annunziato F, Livi C, et al: Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995;155:128–133.
- Saito S, Sakai M, Sasaki Y, Tanabe K, Tsuda H, Michimata T: Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia. Clin Exp Immunol 1999;117:550–555.
- Omu AE, Al-Qattan F, Diejomaoh ME, Al-Yatama M: Differential levels of T helper cytokines in preeclampsia: Pregnancy, labor and puerperium. Acta Obstet Gynecol Scand 1999;78:675–680.
- Saito S, Umekage H, Sakamoto Y, Sakai M, Tanebe K, Sasaki Y, Morikawa H: Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia. Am J Reprod Immunol 1999;41:297–306.
Article / Publication Details
First-Page Preview
Published online: November 17, 2000
Issue release date: November 2000
Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0
ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)
For additional information: https://www.karger.com/GOI
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
