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Original Paper

Editor's Choice - Free Access

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

Van Den Eede F.a, c, d · Moorkens G.b · Van Houdenhove B.e · Cosyns P.a, c · Claes S.J.d, e

Author affiliations

Departments of aPsychiatry and bInternal Medicine, University Hospital Antwerp, Edegem, cCollaborative Antwerp Psychiatric Research Institute, University of Antwerp, dDepartment of Molecular Genetics VIB8, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, and eDepartment of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium

Corresponding Author

Filip Van Den Eede, PhD

Department of Psychiatry, University Hospital Antwerp (UZA)

Wilrijkstraat 10

BE–2650 Edegem (Belgium)

Tel. +32 3 821 49 11, Fax +32 3 825 16 41, E-Mail filip.van.den.eede@uza.be

Related Articles for ""

Neuropsychobiology 2007;55:112–120

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There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and methodological difficulties. In this review, we focus on challenge studies and on the role of the HPA axis in the pathogenesis of CFS. Mild hypocortisolism, blunted adrenocorticotropin response to stressors and enhanced negative feedback sensitivity to glucocorticoids are the main findings. Several underlying mechanisms have been proposed. Currently, it is a matter of debate whether these disturbances have a primary role in the pathogenesis of CFS. However, even if the HPA axis dysfunctions are secondary to other factors, they are probably a relevant factor in symptom propagation in CFS.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 29, 2006
Accepted: March 17, 2007
Published online: June 27, 2007
Issue release date: July 2007

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

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